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Polysomy 17

MedGen UID:
269464
•Concept ID:
C1514214
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolysomy 17

Professional guidelines

PubMed

Evaluation of genetic status of HER-2/neu and aneusomy 17 by fluorescence in situ hybridization and comparison with immunohistochemistry assay from Indian breast cancer patients.
Kokate P, Sawaimoon S, Bhatia S, Mandava S
Genet Test Mol Biomarkers 2012 Apr;16(4):239-45. Epub 2011 Oct 24 doi: 10.1089/gtmb.2011.0125. PMID: 22023243
Adjuvant chemotherapy for the treatment of HER2-positive early breast cancer.
Clavarezza M, Venturini M
Oncology 2009;77 Suppl 1:14-7. Epub 2010 Feb 2 doi: 10.1159/000258491. PMID: 20130427
Performance of chromogenic in situ hybridization on testing HER2 Status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) herceptest results: a study of two institutions using the conventional and new ASCO/CAP scoring criteria.
Gong Y, Sweet W, Duh YJ, Greenfield L, Tarco E, Trivedi S, Symmans WF, Isola J, Sneige N
Am J Clin Pathol 2009 Aug;132(2):228-36. doi: 10.1309/AJCP4M2VUZCLDALN. PMID: 19605817

Recent clinical studies

Etiology

HER2 and TOP2A Gene Amplification and Protein Expression in Upper Tract Urothelial Carcinomas.
Aumayr K, Klatte T, Neudert B, Birner P, Shariat S, Schmidinger M, Susani M, Haitel A
Pathol Oncol Res 2018 Jul;24(3):575-581. Epub 2017 Jul 28 doi: 10.1007/s12253-017-0260-0. PMID: 28755093
Impact of polysomy 17 on HER2 testing of invasive breast cancer patients.
Liu Y, Ma L, Liu D, Yang Z, Yang C, Hu Z, Chen W, Yang Z, Chen S, Zhang Z
Int J Clin Exp Pathol 2014;7(1):163-73. Epub 2013 Dec 15 PMID: 24427336Free PMC Article
Status of HER2 amplification, polysomy 17 and histopathological features of 425 Pakistani breast cancer patients.
Moatter T, Aban M, Iqbal W, Azam I, Pervaiz A, Siddiqui F, Murad F, Pervez S
Asian Pac J Cancer Prev 2011;12(11):3069-73. PMID: 22393991
Genetic alterations and protein expression of HER2 and chromosome 17 polysomy in breast cancer.
Zhu X, Lu Y, Lu H, Yang W, Tu X, Cai X, Zhou X
Hum Pathol 2011 Oct;42(10):1499-504. Epub 2011 Jun 14 doi: 10.1016/j.humpath.2010.04.023. PMID: 21676436
The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study.
Downs-Kelly E, Yoder BJ, Stoler M, Tubbs RR, Skacel M, Grogan T, Roche P, Hicks DG
Am J Surg Pathol 2005 Sep;29(9):1221-7. doi: 10.1097/01.pas.0000165528.78945.95. PMID: 16096413

Diagnosis

Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity.
Hanna WM, Rüschoff J, Bilous M, Coudry RA, Dowsett M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G
Mod Pathol 2014 Jan;27(1):4-18. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.103. PMID: 23807776
Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.
Luo Y, Qiu Z, Tian L, Zhu G, Feng Y, Yi M, Chen X, Wang L, Li C, Huang Q
Hum Pathol 2013 Jan;44(1):69-76. Epub 2012 Aug 30 doi: 10.1016/j.humpath.2012.04.014. PMID: 22939953
Role of polysomy 17 in transitional cell carcinoma of the bladder: immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17.
Simonetti S, Russo R, Ciancia G, Altieri V, De Rosa G, Insabato L
Int J Surg Pathol 2009 Jun;17(3):198-205. doi: 10.1177/1066896909333415. PMID: 19443884
Does polysomy of chromosome 17 have a role in ERBB2 and topoisomerase IIalpha expression? Gene, mRNA and protein expression: a comprehensive analysis.
Corzo C, Bellosillo B, Corominas JM, Salido M, Coll MD, Serrano S, Albanell J, Solé F, Tusquets I
Tumour Biol 2007;28(4):221-8. Epub 2007 Aug 23 doi: 10.1159/000107583. PMID: 17717428

Therapy

Monosomy 17 in potentially curable HER2-amplified breast cancer: prognostic and predictive impact.
Page DB, Wen H, Brogi E, Dure D, Ross D, Spinelli KJ, Patil S, Norton L, Hudis C, McArthur HL
Breast Cancer Res Treat 2018 Jan;167(2):547-554. Epub 2017 Oct 6 doi: 10.1007/s10549-017-4520-1. PMID: 28986743Free PMC Article
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity.
Hanna WM, Rüschoff J, Bilous M, Coudry RA, Dowsett M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G
Mod Pathol 2014 Jan;27(1):4-18. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.103. PMID: 23807776
Status of HER2 amplification, polysomy 17 and histopathological features of 425 Pakistani breast cancer patients.
Moatter T, Aban M, Iqbal W, Azam I, Pervaiz A, Siddiqui F, Murad F, Pervez S
Asian Pac J Cancer Prev 2011;12(11):3069-73. PMID: 22393991
The important molecular markers on chromosome 17 and their clinical impact in breast cancer.
Zhang W, Yu Y
Int J Mol Sci 2011;12(9):5672-83. Epub 2011 Sep 5 doi: 10.3390/ijms12095672. PMID: 22016618Free PMC Article

Prognosis

The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer.
Katayama A, Starczynski J, Toss MS, Shaaban AM, Provenzano E, Quinn CM, Callagy G, Purdie CA, Millican-Slater R, Purnell D, Chagla L, Oyama T, Pinder SE, Chan S, Ellis I, Lee AHS, Rakha EA
Histopathology 2022 Oct;81(4):511-519. Epub 2022 Aug 8 doi: 10.1111/his.14728. PMID: 35879836Free PMC Article
HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity.
Hanna WM, Rüschoff J, Bilous M, Coudry RA, Dowsett M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G
Mod Pathol 2014 Jan;27(1):4-18. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.103. PMID: 23807776
Chromosome 17 polysomy: correlation with histological parameters and HER2NEU gene amplification.
Orsaria M, Khelifa S, Buza N, Kamath A, Hui P
J Clin Pathol 2013 Dec;66(12):1070-5. Epub 2013 Aug 1 doi: 10.1136/jclinpath-2013-201506. PMID: 23908451
Status of HER2 amplification, polysomy 17 and histopathological features of 425 Pakistani breast cancer patients.
Moatter T, Aban M, Iqbal W, Azam I, Pervaiz A, Siddiqui F, Murad F, Pervez S
Asian Pac J Cancer Prev 2011;12(11):3069-73. PMID: 22393991
Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response.
Reinholz MM, Bruzek AK, Visscher DW, Lingle WL, Schroeder MJ, Perez EA, Jenkins RB
Lancet Oncol 2009 Mar;10(3):267-77. doi: 10.1016/S1470-2045(09)70063-4. PMID: 19261255Free PMC Article

Clinical prediction guides

The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer.
Katayama A, Starczynski J, Toss MS, Shaaban AM, Provenzano E, Quinn CM, Callagy G, Purdie CA, Millican-Slater R, Purnell D, Chagla L, Oyama T, Pinder SE, Chan S, Ellis I, Lee AHS, Rakha EA
Histopathology 2022 Oct;81(4):511-519. Epub 2022 Aug 8 doi: 10.1111/his.14728. PMID: 35879836Free PMC Article
HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity.
Hanna WM, Rüschoff J, Bilous M, Coudry RA, Dowsett M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G
Mod Pathol 2014 Jan;27(1):4-18. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.103. PMID: 23807776
Chromosome 17 polysomy: correlation with histological parameters and HER2NEU gene amplification.
Orsaria M, Khelifa S, Buza N, Kamath A, Hui P
J Clin Pathol 2013 Dec;66(12):1070-5. Epub 2013 Aug 1 doi: 10.1136/jclinpath-2013-201506. PMID: 23908451
Status of HER2 amplification, polysomy 17 and histopathological features of 425 Pakistani breast cancer patients.
Moatter T, Aban M, Iqbal W, Azam I, Pervaiz A, Siddiqui F, Murad F, Pervez S
Asian Pac J Cancer Prev 2011;12(11):3069-73. PMID: 22393991
Genetic alterations and protein expression of HER2 and chromosome 17 polysomy in breast cancer.
Zhu X, Lu Y, Lu H, Yang W, Tu X, Cai X, Zhou X
Hum Pathol 2011 Oct;42(10):1499-504. Epub 2011 Jun 14 doi: 10.1016/j.humpath.2010.04.023. PMID: 21676436

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