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Vitreous detachment

MedGen UID:
21884
•Concept ID:
C0042907
•
Disease or Syndrome
Synonyms: Detachment, Vitreous; Detachments, Vitreous; Vitreous Detachment; Vitreous Detachments
SNOMED CT: Vitreous separation (53772007); Vitreous detachment (53772007)

Definition

The separation of the vitreous from the retina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitreous detachment

Professional guidelines

PubMed

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
To Treat or Not to Treat: Management Options for Symptomatic Vitreous Floaters.
Broadhead GK, Hong T, Chang AA
Asia Pac J Ophthalmol (Phila) 2020 Mar-Apr;9(2):96-103. doi: 10.1097/APO.0000000000000276. PMID: 32097127
Vitreous floaters: Etiology, diagnostics, and management.
Milston R, Madigan MC, Sebag J
Surv Ophthalmol 2016 Mar-Apr;61(2):211-27. Epub 2015 Dec 8 doi: 10.1016/j.survophthal.2015.11.008. PMID: 26679984

Recent clinical studies

Etiology

Complications of Acute Posterior Vitreous Detachment.
Seider MI, Conell C, Melles RB
Ophthalmology 2022 Jan;129(1):67-72. Epub 2021 Jul 27 doi: 10.1016/j.ophtha.2021.07.020. PMID: 34324945
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
Flashes and Floaters.
Sharma P, Sridhar J, Mehta S
Prim Care 2015 Sep;42(3):425-35. doi: 10.1016/j.pop.2015.05.011. PMID: 26319347
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Diagnosis

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
Flashes and Floaters.
Sharma P, Sridhar J, Mehta S
Prim Care 2015 Sep;42(3):425-35. doi: 10.1016/j.pop.2015.05.011. PMID: 26319347
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Therapy

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Pharmacotherapy of Vitreomacular Traction.
Wan R, Hong T, Tariq Y, Chang A
Curr Pharm Des 2018;24(41):4874-4881. doi: 10.2174/1381612825666190124102148. PMID: 30674252
Enzymatic vitreolysis.
Lopez-Lopez F, Rodriguez-Blanco M, Gómez-Ulla F, Marticorena J
Curr Diabetes Rev 2009 Feb;5(1):57-62. doi: 10.2174/157339909787314220. PMID: 19199900
Enzymatic vitreous disruption.
Gandorfer A
Eye (Lond) 2008 Oct;22(10):1273-7. Epub 2008 Feb 22 doi: 10.1038/eye.2008.29. PMID: 18292784
Pharmacologic vitreolysis.
Gandorfer A
Dev Ophthalmol 2007;39:149-156. doi: 10.1159/000098505. PMID: 17245084

Prognosis

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Vitreous floaters.
Roufail ED, Polkinghorne P
Compr Ophthalmol Update 2006 Jul-Aug;7(4):171-7. PMID: 17007730
Vitreous Hemorrhage.
Spraul CW, Grossniklaus HE
Surv Ophthalmol 1997 Jul-Aug;42(1):3-39. doi: 10.1016/s0039-6257(97)84041-6. PMID: 9265701

Clinical prediction guides

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Asymmetric diabetic retinopathy.
Azad R, Sinha S, Nishant P
Indian J Ophthalmol 2021 Nov;69(11):3026-3034. doi: 10.4103/ijo.IJO_1525_21. PMID: 34708738Free PMC Article
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
Vitreous floaters: Etiology, diagnostics, and management.
Milston R, Madigan MC, Sebag J
Surv Ophthalmol 2016 Mar-Apr;61(2):211-27. Epub 2015 Dec 8 doi: 10.1016/j.survophthal.2015.11.008. PMID: 26679984
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Recent systematic reviews

Ocriplasmin for treatment of vitreomacular traction and macular hole: A systematic literature review and individual participant data meta-analysis of randomized, controlled, double-masked trials.
Jackson TL, Haller J, Blot KH, Duchateau L, Lescrauwaet B
Surv Ophthalmol 2022 May-Jun;67(3):697-711. Epub 2021 Sep 2 doi: 10.1016/j.survophthal.2021.08.003. PMID: 34480895
Symptoms related to posterior vitreous detachment and the risk of developing retinal tears: a systematic review.
Gishti O, van den Nieuwenhof R, Verhoekx J, van Overdam K
Acta Ophthalmol 2019 Jun;97(4):347-352. Epub 2019 Jan 11 doi: 10.1111/aos.14012. PMID: 30632695
Ocriplasmin for symptomatic vitreomacular adhesion.
Neffendorf JE, Kirthi V, Pringle E, Jackson TL
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD011874. doi: 10.1002/14651858.CD011874.pub2. PMID: 29040800Free PMC Article
Prophylactic treatment of retinal breaks--a systematic review.
Blindbaek S, Grauslund J
Acta Ophthalmol 2015 Feb;93(1):3-8. Epub 2014 May 22 doi: 10.1111/aos.12447. PMID: 24853827
Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion: a systematic review and metaanalysis.
Jackson TL, Nicod E, Angelis A, Grimaccia F, Prevost AT, Simpson AR, Kanavos P
Retina 2013 Jun;33(6):1099-108. doi: 10.1097/IAE.0b013e31828991d6. PMID: 23591535

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