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Elevated circulating thrombopoietin concentration

MedGen UID:
1841753
•Concept ID:
C5826512
•
Finding
Synonym: Thrombopoietin high in blood
 
HPO: HP:0034600

Definition

Concentration of thrombopoietin in the blood circulation above the upper limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating thrombopoietin concentration

Recent clinical studies

Etiology

Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Thrombopoietin Contributes to Enhanced Platelet Activation in Patients with Type 1 Diabetes Mellitus.
Bosco O, Vizio B, Gruden G, Schiavello M, Lorenzati B, Cavallo-Perin P, Russo I, Montrucchio G, Lupia E
Int J Mol Sci 2021 Jun 29;22(13) doi: 10.3390/ijms22137032. PMID: 34210000Free PMC Article
In multiple myeloma increased thrombopoietin (Tpo) production may be involved in the maintenance of platelet production.
Folman CC, de Jong CM, de Haas M, von dem Borne AE
Eur J Haematol 2001 May;66(5):337-41. doi: 10.1034/j.1600-0609.2001.066005337.x. PMID: 11422414
Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis.
Hsu HC, Tsai WH, Jiang ML, Ho CH, Hsu ML, Ho CK, Wang SY
J Lab Clin Med 1999 Oct;134(4):392-7. doi: 10.1016/s0022-2143(99)90154-3. PMID: 10521086
Thrombocytosis after major lower extremity trauma: mechanism and possible role in free flap failure.
Choe EI, Kasabian AK, Kolker AR, Karp NS, Zhang L, Bass LS, Nardi M, Josephson G, Karpatkin M
Ann Plast Surg 1996 May;36(5):489-94. doi: 10.1097/00000637-199605000-00010. PMID: 8743659

Diagnosis

Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes.
Hou M, Andersson PO, Stockelberg D, Mellqvist UH, Ridell B, Wadenvik H
Br J Haematol 1998 Jun;101(3):420-4. doi: 10.1046/j.1365-2141.1998.00747.x. PMID: 9633881

Therapy

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.
Zhao X, Feng X, Wu Z, Winkler T, Desmond R, Olnes M, Dumitriu B, Townsley DM, Dunbar CE, Young NS
Exp Hematol 2018 Feb;58:39-43. Epub 2017 Sep 20 doi: 10.1016/j.exphem.2017.09.006. PMID: 28941711Free PMC Article
Thrombocytopenia caused by the development of antibodies to thrombopoietin.
Li J, Yang C, Xia Y, Bertino A, Glaspy J, Roberts M, Kuter DJ
Blood 2001 Dec 1;98(12):3241-8. doi: 10.1182/blood.v98.12.3241. PMID: 11719360
Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis.
Murray LJ, Luens KM, Estrada MF, Bruno E, Hoffman R, Cohen RL, Ashby MA, Vadhan-Raj S
Exp Hematol 1998 Mar;26(3):207-16. PMID: 9502616
Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia.
Heits F, Katschinski DM, Wilmsen U, Wiedemann GJ, Jelkmann W
Eur J Haematol 1997 Jul;59(1):53-8. doi: 10.1111/j.1600-0609.1997.tb00959.x. PMID: 9260581
Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation.
Meng YG, Martin TG, Peterson ML, Shuman MA, Cohen RL, Wong WL
Br J Haematol 1996 Dec;95(3):535-41. doi: 10.1046/j.1365-2141.1996.d01-1933.x. PMID: 8943898

Prognosis

Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes.
Zwierzina H, Rollinger-Holzinger I, Nuessler V, Herold M, Meng YG
Leukemia 1998 Jan;12(1):59-64. doi: 10.1038/sj.leu.2400901. PMID: 9436921
Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice.
Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ
Blood 1997 Sep 1;90(5):1821-7. PMID: 9292514

Clinical prediction guides

Increase in circulating bone marrow progenitor cells after myocardial infarction.
Spevack DM, Cavaleri S, Zolotarev A, Liebes L, Inghirami G, Tunick PA, Kronzon I
Coron Artery Dis 2006 May;17(4):345-9. doi: 10.1097/00019501-200606000-00004. PMID: 16707957
Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis.
Murray LJ, Luens KM, Estrada MF, Bruno E, Hoffman R, Cohen RL, Ashby MA, Vadhan-Raj S
Exp Hematol 1998 Mar;26(3):207-16. PMID: 9502616
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.
Wiestner A, Schlemper RJ, van der Maas AP, Skoda RC
Nat Genet 1998 Jan;18(1):49-52. doi: 10.1038/ng0198-49. PMID: 9425899
Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice.
Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ
Blood 1997 Sep 1;90(5):1821-7. PMID: 9292514

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