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Large keratohyaline granules

MedGen UID:
1841680
•Concept ID:
C5826775
•
Finding
HPO: HP:0034927

Definition

Abnormally large keratohyalin granules (KHG). KHG are typically present in the stratum granulosum of the epidermal layer of the skin (and epithelium of the mucosae). KHG are protein structures found in the keratinocytes of the stratum granulosum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge keratohyaline granules

Recent clinical studies

Therapy

Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibody.
Takahashi M, Horiuchi Y, Tezuka T
Br J Dermatol 2005 Nov;153(5):976-80. doi: 10.1111/j.1365-2133.2005.06866.x. PMID: 16225609

Clinical prediction guides

Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibody.
Takahashi M, Horiuchi Y, Tezuka T
Br J Dermatol 2005 Nov;153(5):976-80. doi: 10.1111/j.1365-2133.2005.06866.x. PMID: 16225609

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