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Decreased circulating thyrotropin releasing hormone concentration

MedGen UID:
1841636
•Concept ID:
C5826754
•
Finding
Synonyms: Decreased circulating TRH concentration; Thyrotropin releasing hormone (TRH) low in blood
 
HPO: HP:0034904

Definition

Concentration of thyrotropin releasing hormone below the lower limit of normal in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating thyrotropin releasing hormone concentration

Recent clinical studies

Etiology

Afferent signals regulating food intake.
Bray GA
Proc Nutr Soc 2000 Aug;59(3):373-84. doi: 10.1017/s0029665100000422. PMID: 10997653
Normal thyroxine and elevated thyrotropin concentrations: evolving hypothyroidism or persistent euthyroidism with reset thyrostat.
Kabadi UM, Cech R
J Endocrinol Invest 1997 Jun;20(6):319-26. doi: 10.1007/BF03350310. PMID: 9294777
Hypothalamic-pituitary-thyroidal function in eumenorrheic and amenorrheic athletes.
Loucks AB, Laughlin GA, Mortola JF, Girton L, Nelson JC, Yen SS
J Clin Endocrinol Metab 1992 Aug;75(2):514-8. doi: 10.1210/jcem.75.2.1639953. PMID: 1639953
Effect of acute hypercalcemia on thyrotropin (TSH) and triiodothyronine responses to TSH-releasing hormone in man.
Gillet C, Corvilain J, Matte-Hiriart J, Willems D, Bergmann P
J Clin Endocrinol Metab 1990 Aug;71(2):516-9. doi: 10.1210/jcem-71-2-516. PMID: 2116441
Thyroid function in thalassaemia major.
de Luca F, Melluso R, Sobbrio G, Canfora G, Trimarchi F
Arch Dis Child 1980 May;55(5):389-92. doi: 10.1136/adc.55.5.389. PMID: 6776904Free PMC Article

Diagnosis

Hypothalamic-pituitary-thyroidal dysfunctions in anorexia nervosa.
Tamai H, Mori K, Matsubayashi S, Kiyohara K, Nakagawa T, Okimura MC, Walter RM Jr, Kumagai LF, Nagataki S
Psychother Psychosom 1986;46(3):127-31. doi: 10.1159/000287973. PMID: 3114819
Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.
Johnston DG, Haigh J, Prescott RW, Heaton A, Kendall-Taylor P, Baylis P, Alberti KG, Rowe R, Friesen H, Cook D
Clin Endocrinol (Oxf) 1985 May;22(5):661-78. doi: 10.1111/j.1365-2265.1985.tb03003.x. PMID: 3928210
Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes.
Abe K, Matsuura N, Fukushima N, Nohara Y, Fujita H, Fujieda K, Kato T
Tohoku J Exp Med 1983 May;140(1):29-34. doi: 10.1620/tjem.140.29. PMID: 6408763
Assessment of thyroid function.
Surks MI
Ophthalmology 1981 Jun;88(6):476-8. doi: 10.1016/s0161-6420(81)35000-3. PMID: 6791080
Hyperthyroidism in the elderly.
Kawabe T, Komiya I, Endo T, Koizumi Y, Yamada T
J Am Geriatr Soc 1979 Apr;27(4):152-5. doi: 10.1111/j.1532-5415.1979.tb06438.x. PMID: 107212

Therapy

Increased serum concentration of nerve growth factor in patients with microprolactinoma.
Sigala S, Martocchia A, Missale C, Falaschi P, Spano P
Neuropeptides 2004 Feb;38(1):21-4. doi: 10.1016/j.npep.2003.11.002. PMID: 15003712
Effect of acute hypercalcemia on thyrotropin (TSH) and triiodothyronine responses to TSH-releasing hormone in man.
Gillet C, Corvilain J, Matte-Hiriart J, Willems D, Bergmann P
J Clin Endocrinol Metab 1990 Aug;71(2):516-9. doi: 10.1210/jcem-71-2-516. PMID: 2116441
Thyroid hormone concentrations in epileptic patients.
Larkin JG, Macphee GJ, Beastall GH, Brodie MJ
Eur J Clin Pharmacol 1989;36(3):213-6. doi: 10.1007/BF00558149. PMID: 2501100
Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes.
Abe K, Matsuura N, Fukushima N, Nohara Y, Fujita H, Fujieda K, Kato T
Tohoku J Exp Med 1983 May;140(1):29-34. doi: 10.1620/tjem.140.29. PMID: 6408763
Hyperthyroidism in the elderly.
Kawabe T, Komiya I, Endo T, Koizumi Y, Yamada T
J Am Geriatr Soc 1979 Apr;27(4):152-5. doi: 10.1111/j.1532-5415.1979.tb06438.x. PMID: 107212

Prognosis

An ultrarapid prognostic index in microprolactinoma surgery.
Guieu R, Dufour H, Grisoli F, Jaquet P, Guieu Y, Rosso JP, Munier M, Dicostanzo V, Brue T, Enjalbert A, Begoud D, Rochat H
J Neurosurg 1999 Jun;90(6):1037-41. doi: 10.3171/jns.1999.90.6.1037. PMID: 10350249
Normal thyroxine and elevated thyrotropin concentrations: evolving hypothyroidism or persistent euthyroidism with reset thyrostat.
Kabadi UM, Cech R
J Endocrinol Invest 1997 Jun;20(6):319-26. doi: 10.1007/BF03350310. PMID: 9294777
Effects of nonthyroidal illness on thyroid function.
Tibaldi JM, Surks MI
Med Clin North Am 1985 Sep;69(5):899-911. doi: 10.1016/s0025-7125(16)30996-8. PMID: 3932793
Effect of Iopanoic acid on the pituitary-thyroid axis: time sequence of changes in serum iodothyronines, thyrotropin, and prolactin concentrations and responses to thyroid hormones.
Suzuki H, Noguchi K, Nakahata M, Nakagawa S, Kadena N
J Clin Endocrinol Metab 1981 Oct;53(4):779-83. doi: 10.1210/jcem-53-4-779. PMID: 6793610
Amenorrhea, hyperprolactinemia and pituitary enlargement secondary to primary hypothyroidism. Successful treatment with thyroid replacement.
Keye WR, Yuen BH, Knopf RF, Jaffe RB
Obstet Gynecol 1976 Dec;48(6):697-702. PMID: 825796

Clinical prediction guides

Pituitary function in children with hydrocephalus before and after the first shunting operation.
Löppönen T, Saukkonen AL, Serlo W, Tapanainen P, Ruokonen A, Lanning P, Knip M
Eur J Endocrinol 1998 Feb;138(2):170-5. doi: 10.1530/eje.0.1380170. PMID: 9506861
L-thyroxine treatment of preterm newborns: clinical and endocrine effects.
Vanhole C, Aerssens P, Naulaers G, Casneuf A, Devlieger H, Van den Berghe G, de Zegher F
Pediatr Res 1997 Jul;42(1):87-92. doi: 10.1203/00006450-199707000-00014. PMID: 9212042
Hypothalamic-pituitary-thyroidal function in eumenorrheic and amenorrheic athletes.
Loucks AB, Laughlin GA, Mortola JF, Girton L, Nelson JC, Yen SS
J Clin Endocrinol Metab 1992 Aug;75(2):514-8. doi: 10.1210/jcem.75.2.1639953. PMID: 1639953
Effect of acute hypercalcemia on thyrotropin (TSH) and triiodothyronine responses to TSH-releasing hormone in man.
Gillet C, Corvilain J, Matte-Hiriart J, Willems D, Bergmann P
J Clin Endocrinol Metab 1990 Aug;71(2):516-9. doi: 10.1210/jcem-71-2-516. PMID: 2116441
Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.
Johnston DG, Haigh J, Prescott RW, Heaton A, Kendall-Taylor P, Baylis P, Alberti KG, Rowe R, Friesen H, Cook D
Clin Endocrinol (Oxf) 1985 May;22(5):661-78. doi: 10.1111/j.1365-2265.1985.tb03003.x. PMID: 3928210

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