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Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma

MedGen UID:
1769546
•Concept ID:
C5418961
•
Neoplastic Process
Synonyms: HPV-Associated Mucosal Head and Neck Squamous Cell Carcinoma; HPV-Related Mucosal Head and Neck Squamous Cell Carcinoma; Human Papillomavirus-Associated Mucosal Head and Neck Squamous Cell Carcinoma

Definition

A squamous cell carcinoma associated with human papilloma virus, arising from the mucosal sites of head and neck. [from NCI]

Professional guidelines

PubMed

Management of unknown primary head and neck cancer with radiation therapy in the era of human papillomavirus (HPV): No longer cutting down the tree to get an apple.
Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736

Recent clinical studies

Etiology

A Prospective Study of Mucosal Sparing Radiation Therapy in Resected Oropharyngeal Cancer Patients.
Anderson JD, DeWees TA, Ma DJ, Nagel TH, Van Abel KM, Moore EJ, Rwigema JCM, Routman DM, Wittich MN, McGee LA, Hayden RE, Foote RL, Golafshar M, Gamez ME, Lester SC, Anand A, Crujido LR, Halyard MY, Hinni ML, Patel SH
Int J Radiat Oncol Biol Phys 2023 Jan 1;115(1):192-201. Epub 2022 Oct 26 doi: 10.1016/j.ijrobp.2022.06.057. PMID: 36309077
Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656

Diagnosis

Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656

Therapy

A Prospective Study of Mucosal Sparing Radiation Therapy in Resected Oropharyngeal Cancer Patients.
Anderson JD, DeWees TA, Ma DJ, Nagel TH, Van Abel KM, Moore EJ, Rwigema JCM, Routman DM, Wittich MN, McGee LA, Hayden RE, Foote RL, Golafshar M, Gamez ME, Lester SC, Anand A, Crujido LR, Halyard MY, Hinni ML, Patel SH
Int J Radiat Oncol Biol Phys 2023 Jan 1;115(1):192-201. Epub 2022 Oct 26 doi: 10.1016/j.ijrobp.2022.06.057. PMID: 36309077
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656

Prognosis

Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.
Andreasen S, Bishop JA, Hansen TV, Westra WH, Bilde A, von Buchwald C, Kiss K
Histopathology 2017 May;70(6):880-888. Epub 2017 Feb 24 doi: 10.1111/his.13162. PMID: 28035703

Clinical prediction guides

A Prospective Study of Mucosal Sparing Radiation Therapy in Resected Oropharyngeal Cancer Patients.
Anderson JD, DeWees TA, Ma DJ, Nagel TH, Van Abel KM, Moore EJ, Rwigema JCM, Routman DM, Wittich MN, McGee LA, Hayden RE, Foote RL, Golafshar M, Gamez ME, Lester SC, Anand A, Crujido LR, Halyard MY, Hinni ML, Patel SH
Int J Radiat Oncol Biol Phys 2023 Jan 1;115(1):192-201. Epub 2022 Oct 26 doi: 10.1016/j.ijrobp.2022.06.057. PMID: 36309077
Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656

Recent systematic reviews

Management of unknown primary head and neck cancer with radiation therapy in the era of human papillomavirus (HPV): No longer cutting down the tree to get an apple.
Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736

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