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Advanced Pharyngeal Squamous Cell Carcinoma

MedGen UID:
1769475
•Concept ID:
C5420343
•
Neoplastic Process

Definition

Pharyngeal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
ACR Appropriateness criteria® for nasopharyngeal carcinoma.
Saba NF, Salama JK, Beitler JJ, Busse PM, Cooper JS, Jones CU, Koyfman S, Quon H, Ridge JA, Siddiqui F, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology-Head and Neck Cancer
Head Neck 2016 Jul;38(7):979-86. Epub 2016 Apr 30 doi: 10.1002/hed.24423. PMID: 27131050

Recent clinical studies

Etiology

Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
CDK4/6 inhibitors in P16/HPV16-negative squamous cell carcinoma of the head and neck.
Billard-Sandu C, Tao YG, Sablin MP, Dumitrescu G, Billard D, Deutsch E
Eur Arch Otorhinolaryngol 2020 May;277(5):1273-1280. Epub 2020 Mar 11 doi: 10.1007/s00405-020-05891-2. PMID: 32162057
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Human Papillomavirus-Negative Pharyngeal Cancer.
Dillon MT, Harrington KJ
J Clin Oncol 2015 Oct 10;33(29):3251-61. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.60.7804. PMID: 26351347

Diagnosis

Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.
Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2099-2107. Epub 2021 Jul 28 doi: 10.1007/s00405-021-07007-w. PMID: 34319483
Oral submucous fibrosis in Asian countries.
Peng Q, Li H, Chen J, Wang Y, Tang Z
J Oral Pathol Med 2020 Apr;49(4):294-304. Epub 2019 Jul 16 doi: 10.1111/jop.12924. PMID: 31310693
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Therapy

Advances in Organ Preservation for Laryngeal Cancer.
Campbell G, Glazer TA, Kimple RJ, Bruce JY
Curr Treat Options Oncol 2022 Apr;23(4):594-608. Epub 2022 Mar 18 doi: 10.1007/s11864-022-00945-5. PMID: 35303749Free PMC Article
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Human Papillomavirus-Negative Pharyngeal Cancer.
Dillon MT, Harrington KJ
J Clin Oncol 2015 Oct 10;33(29):3251-61. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.60.7804. PMID: 26351347
Experience with CHART.
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Prognosis

CDK4/6 inhibitors in P16/HPV16-negative squamous cell carcinoma of the head and neck.
Billard-Sandu C, Tao YG, Sablin MP, Dumitrescu G, Billard D, Deutsch E
Eur Arch Otorhinolaryngol 2020 May;277(5):1273-1280. Epub 2020 Mar 11 doi: 10.1007/s00405-020-05891-2. PMID: 32162057
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Human Papillomavirus-Negative Pharyngeal Cancer.
Dillon MT, Harrington KJ
J Clin Oncol 2015 Oct 10;33(29):3251-61. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.60.7804. PMID: 26351347
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Clinical prediction guides

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
Pathological Level VI Lymph Node Metastasis in Clinical N3b Pyriform Sinus Squamous Cell Carcinoma.
Matsui H, Iwae S, Yamamura Y, Horichi Y
Ann Otol Rhinol Laryngol 2022 Aug;131(8):824-828. Epub 2021 Sep 11 doi: 10.1177/00034894211045779. PMID: 34514862
BP180 Is a Prognostic Factor in Head and Neck Squamous Cell Carcinoma.
Meng X, Matsumoto F, Mori T, Miura N, Ino Y, Onidani K, Kobayashi K, Matsuzaki Y, Yoshimoto S, Ikeda K, Honda K
Anticancer Res 2021 Feb;41(2):1089-1099. doi: 10.21873/anticanres.14867. PMID: 33517320
Serum, plasma and saliva biomarkers for head and neck cancer.
Arantes LMRB, De Carvalho AC, Melendez ME, Lopes Carvalho A
Expert Rev Mol Diagn 2018 Jan;18(1):85-112. Epub 2017 Nov 20 doi: 10.1080/14737159.2017.1404906. PMID: 29134827
Cancer of the pharynx and larynx.
Sasaki CT, Jassin B
Am J Med 2001 Dec 3;111 Suppl 8A:118S-123S. doi: 10.1016/s0002-9343(01)00850-6. PMID: 11749936

Recent systematic reviews

Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Outcomes of Endoscopic Submucosal Dissection for Treatment of Superficial Pharyngeal Cancers: Systematic Review and Meta-Analysis.
Kamal F, Khan MA, Lee-Smith W, Sharma S, Imam Z, Jowhar D, Petryna E, Esswein J, Acharya A, Aziz M, Farooq U, Zafar U, Mcdonough S, Adler DG
Dig Dis Sci 2022 Aug;67(8):3518-3528. Epub 2021 Sep 9 doi: 10.1007/s10620-021-07225-6. PMID: 34505257
A systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall.
De Virgilio A, Russo E, Costantino A, Malvezzi L, Colombo G, Cugini G, Miceli S, Rossi V, Spriano G, Mercante G
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2663-2672. Epub 2020 May 2 doi: 10.1007/s00405-020-05990-0. PMID: 32361771
Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: A systematic review.
Kao SS, Peters MD, Krishnan SG, Ooi EH
Laryngoscope 2016 Jul;126(7):1572-80. Epub 2016 Feb 10 doi: 10.1002/lary.25894. PMID: 26865034
Pharyngocutaneous fistula after total laryngectomy: systematic review of risk factors.
Dedivitis RA, Aires FT, Cernea CR, Brandão LG
Head Neck 2015 Nov;37(11):1691-7. Epub 2015 Jun 26 doi: 10.1002/hed.23804. PMID: 24958209

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