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Oropharyngeal Human Papillomavirus-Negative Squamous Cell Carcinoma

MedGen UID:
1755712
•Concept ID:
C5420198
•
Neoplastic Process
Synonyms: Oropharyngeal HPV Negative Squamous Cell Carcinoma; Oropharyngeal HPV-Negative Squamous Cell Carcinoma; Oropharyngeal Human Papillomavirus Negative Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the oropharynx and lacks association with human papillomavirus type 16 infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Human Papillomavirus-Negative Squamous Cell Carcinoma

Professional guidelines

PubMed

Current role of primary surgical treatment in patients with head and neck squamous cell carcinoma.
Bozec A, Culié D, Poissonnet G, Dassonville O
Curr Opin Oncol 2019 May;31(3):138-145. doi: 10.1097/CCO.0000000000000531. PMID: 30865132

Recent clinical studies

Etiology

Females Have Worse Overall and Disease-Specific Survival in Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma.
Hunter WP, Harris JA, Lee CC, Cheng AC, Peacock ZS
J Oral Maxillofac Surg 2022 Jul;80(7):1260-1271. Epub 2022 Mar 28 doi: 10.1016/j.joms.2022.03.017. PMID: 35469827
Human Papillomavirus-Negative Oropharyngeal Cancer Survival Outcomes Based on Primary Treatment: National Cancer Database Analysis.
Shama M, Al-Qurayshi Z, Dahl M, Amdur RJ, Bates J, Mendenhall W, Hitchcock K, Festa BM, Ghanem T, Dziegielewski PT
Otolaryngol Head Neck Surg 2022 Jul;167(1):100-108. Epub 2021 Sep 21 doi: 10.1177/01945998211047169. PMID: 34546828
Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma.
Snietura M, Brewczynski A, Kopec A, Rutkowski T
Pathobiology 2020;87(2):75-86. Epub 2020 Feb 7 doi: 10.1159/000505522. PMID: 32036360
The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus-positive and -negative oropharyngeal squamous cell carcinoma.
Mohamed H, Hagström J, Jouhi L, Atula T, Almangush A, Mäkitie A, Haglund C
Tumour Biol 2019 Mar;41(3):1010428319840473. doi: 10.1177/1010428319840473. PMID: 30915904
Examining adjuvant radiation dose in head and neck squamous cell carcinoma.
Avkshtol V, Handorf EA, Ridge JA, Leachman BK, Liu JC, Bauman J, Galloway TJ
Head Neck 2019 Jul;41(7):2133-2142. Epub 2019 Feb 9 doi: 10.1002/hed.25680. PMID: 30737968Free PMC Article

Diagnosis

Diagnostic Delay in Human Papillomavirus Negative Oropharyngeal Squamous Cell Carcinoma.
Karp EE, Yin LX, O'Byrne TJ, Lu LY, Routman DM, Lester SC, Neben Wittich MA, Ma DJ, Price KA, Chintakuntlawar AV, Tasche KK, Price DL, Moore EJ, Van Abel KM
Laryngoscope 2023 Jun;133(6):1394-1401. Epub 2022 Jul 19 doi: 10.1002/lary.30307. PMID: 35851669
Females Have Worse Overall and Disease-Specific Survival in Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma.
Hunter WP, Harris JA, Lee CC, Cheng AC, Peacock ZS
J Oral Maxillofac Surg 2022 Jul;80(7):1260-1271. Epub 2022 Mar 28 doi: 10.1016/j.joms.2022.03.017. PMID: 35469827
Expression and Role of E-Cadherin, β-Catenin, and Vimentin in Human Papillomavirus-Positive and Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma.
Mohamed H, Haglund C, Jouhi L, Atula T, Hagström J, Mäkitie A
J Histochem Cytochem 2020 Sep;68(9):595-606. Epub 2020 Aug 14 doi: 10.1369/0022155420950841. PMID: 32794417Free PMC Article
Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma.
Snietura M, Brewczynski A, Kopec A, Rutkowski T
Pathobiology 2020;87(2):75-86. Epub 2020 Feb 7 doi: 10.1159/000505522. PMID: 32036360
The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus-positive and -negative oropharyngeal squamous cell carcinoma.
Mohamed H, Hagström J, Jouhi L, Atula T, Almangush A, Mäkitie A, Haglund C
Tumour Biol 2019 Mar;41(3):1010428319840473. doi: 10.1177/1010428319840473. PMID: 30915904

Therapy

Association of Surgical Margin Distance With Survival in Patients With Resected Head and Neck Squamous Cell Carcinoma: A Secondary Analysis of a Randomized Clinical Trial.
Sunkara PR, Graff JT, Cramer JD
JAMA Otolaryngol Head Neck Surg 2023 Apr 1;149(4):317-326. doi: 10.1001/jamaoto.2022.5186. PMID: 36821132Free PMC Article
A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101.
Jelinek MJ, Foster NR, Zoroufy AJ, Schwartz GK, Munster PN, Seiwert TY, de Souza JA, Vokes EE
Oral Oncol 2021 Mar;114:105171. Epub 2021 Jan 26 doi: 10.1016/j.oraloncology.2020.105171. PMID: 33513474Free PMC Article
Current role of primary surgical treatment in patients with head and neck squamous cell carcinoma.
Bozec A, Culié D, Poissonnet G, Dassonville O
Curr Opin Oncol 2019 May;31(3):138-145. doi: 10.1097/CCO.0000000000000531. PMID: 30865132
Heterogeneity and irregularity of pretreatment (18)F-fluorodeoxyglucose positron emission tomography improved prognostic stratification of p16-negative high-risk squamous cell carcinoma of the oropharynx.
Cheng NM, Fang YD, Tsan DL, Lee LY, Chang JT, Wang HM, Ng SH, Liao CT, Yang LY, Yen TC
Oral Oncol 2018 Mar;78:156-162. Epub 2018 Feb 20 doi: 10.1016/j.oraloncology.2018.01.030. PMID: 29496044
FDG PET/CT imaging of oropharyngeal squamous cell carcinoma: characteristics of human papillomavirus-positive and -negative tumors.
Tahari AK, Alluri KC, Quon H, Koch W, Wahl RL, Subramaniam RM
Clin Nucl Med 2014 Mar;39(3):225-31. doi: 10.1097/RLU.0000000000000255. PMID: 24152652Free PMC Article

Prognosis

Diagnostic Delay in Human Papillomavirus Negative Oropharyngeal Squamous Cell Carcinoma.
Karp EE, Yin LX, O'Byrne TJ, Lu LY, Routman DM, Lester SC, Neben Wittich MA, Ma DJ, Price KA, Chintakuntlawar AV, Tasche KK, Price DL, Moore EJ, Van Abel KM
Laryngoscope 2023 Jun;133(6):1394-1401. Epub 2022 Jul 19 doi: 10.1002/lary.30307. PMID: 35851669
Females Have Worse Overall and Disease-Specific Survival in Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma.
Hunter WP, Harris JA, Lee CC, Cheng AC, Peacock ZS
J Oral Maxillofac Surg 2022 Jul;80(7):1260-1271. Epub 2022 Mar 28 doi: 10.1016/j.joms.2022.03.017. PMID: 35469827
Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma.
Snietura M, Brewczynski A, Kopec A, Rutkowski T
Pathobiology 2020;87(2):75-86. Epub 2020 Feb 7 doi: 10.1159/000505522. PMID: 32036360
The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus-positive and -negative oropharyngeal squamous cell carcinoma.
Mohamed H, Hagström J, Jouhi L, Atula T, Almangush A, Mäkitie A, Haglund C
Tumour Biol 2019 Mar;41(3):1010428319840473. doi: 10.1177/1010428319840473. PMID: 30915904
Examining adjuvant radiation dose in head and neck squamous cell carcinoma.
Avkshtol V, Handorf EA, Ridge JA, Leachman BK, Liu JC, Bauman J, Galloway TJ
Head Neck 2019 Jul;41(7):2133-2142. Epub 2019 Feb 9 doi: 10.1002/hed.25680. PMID: 30737968Free PMC Article

Clinical prediction guides

Prognostic significance of cyclin D1 expression pattern in HPV-negative oral and oropharyngeal carcinoma: A deep-learning approach.
Yang K, Zhu G, Sun Y, Hu Y, Lv Y, Li Y, Pan J, Chen F, Zhou Y, Zhang J
J Oral Pathol Med 2023 Nov;52(10):919-929. Epub 2023 Sep 13 doi: 10.1111/jop.13482. PMID: 37701976
Association of Surgical Margin Distance With Survival in Patients With Resected Head and Neck Squamous Cell Carcinoma: A Secondary Analysis of a Randomized Clinical Trial.
Sunkara PR, Graff JT, Cramer JD
JAMA Otolaryngol Head Neck Surg 2023 Apr 1;149(4):317-326. doi: 10.1001/jamaoto.2022.5186. PMID: 36821132Free PMC Article
Females Have Worse Overall and Disease-Specific Survival in Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma.
Hunter WP, Harris JA, Lee CC, Cheng AC, Peacock ZS
J Oral Maxillofac Surg 2022 Jul;80(7):1260-1271. Epub 2022 Mar 28 doi: 10.1016/j.joms.2022.03.017. PMID: 35469827
Human Papillomavirus-Negative Oropharyngeal Cancer Survival Outcomes Based on Primary Treatment: National Cancer Database Analysis.
Shama M, Al-Qurayshi Z, Dahl M, Amdur RJ, Bates J, Mendenhall W, Hitchcock K, Festa BM, Ghanem T, Dziegielewski PT
Otolaryngol Head Neck Surg 2022 Jul;167(1):100-108. Epub 2021 Sep 21 doi: 10.1177/01945998211047169. PMID: 34546828
A matched pair analysis of oncological outcomes in human papillomavirus-negative oropharyngeal squamous cell carcinoma: Transoral surgery versus radiotherapy or concurrent chemoradiation.
Thakar A, Panda S, Kakkar A, Singh V, Singh CA, Sharma A, Bhasker S, Krishnamurthy P, Sharma SC
Head Neck 2021 Oct;43(10):2896-2906. Epub 2021 May 29 doi: 10.1002/hed.26771. PMID: 34050557

Recent systematic reviews

Systematic review on location and timing of distant progression in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas.
Tiedemann D, Jakobsen KK, von Buchwald C, Grønhøj C
Head Neck 2019 Mar;41(3):793-798. Epub 2018 Dec 23 doi: 10.1002/hed.25458. PMID: 30582231

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