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Decreased pituitary glycoprotein hormone alpha subunit level

MedGen UID:
1704144
•Concept ID:
C5139373
•
Finding
Synonyms: Decreased pituitary glycoprotein alpha subunit level; Decreased pituitary glycoprotein polypeptide alpha subunit level
 
HPO: HP:0032482

Definition

An reduced concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased pituitary glycoprotein hormone alpha subunit level

Professional guidelines

PubMed

Free alpha-subunit is the most sensitive marker of gonadotropin recovery after treatment of central precocious puberty with the histrelin implant.
Hirsch HJ, Lahlou N, Gillis D, Strich D, Rosenberg-Hagen B, Chertin B, Farkas A, Hartman H, Spitz IM
J Clin Endocrinol Metab 2010 Jun;95(6):2841-4. Epub 2010 Mar 25 doi: 10.1210/jc.2009-2078. PMID: 20339028
Pituitary surgery for the management of acromegaly.
Laws ER, Vance ML, Thapar K
Horm Res 2000;53 Suppl 3:71-5. doi: 10.1159/000023538. PMID: 10971109
Short-term pre-surgical treatment with somatostatin analogues, octreotide and lanreotide, in acromegaly.
Waśko R, Ruchała M, Sawicka J, Kotwicka M, Liebert W, Sowiński J
J Endocrinol Invest 2000 Jan;23(1):12-8. doi: 10.1007/BF03343669. PMID: 10698045

Recent clinical studies

Etiology

The effects of insulin and liraglutide on osteoprotegerin and vascular calcification in vitro and in patients with type 2 diabetes.
Davenport C, Mahmood WA, Forde H, Ashley DT, Agha A, McDermott J, Sreenan S, Thompson CJ, McGrath F, McAdam B, Cummins PM, Smith D
Eur J Endocrinol 2015 Jul;173(1):53-61. doi: 10.1530/EJE-14-1137. PMID: 26036811
Maturation of hypothalamic-pituitary-gonadal function in normal human fetuses: circulating levels of gonadotropins, their common alpha-subunit and free testosterone, and discrepancy between immunological and biological activities of circulating follicle-stimulating hormone.
Beck-Peccoz P, Padmanabhan V, Baggiani AM, Cortelazzi D, Buscaglia M, Medri G, Marconi AM, Pardi G, Beitins IZ
J Clin Endocrinol Metab 1991 Sep;73(3):525-32. doi: 10.1210/jcem-73-3-525. PMID: 1908479
Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro.
Klibanski A, Alexander JM, Bikkal HA, Hsu DW, Swearingen B, Zervas NT
J Clin Endocrinol Metab 1991 Dec;73(6):1248-55. doi: 10.1210/jcem-73-6-1248. PMID: 1720125
Secretion of alpha-subunit and intact gonadotropins after surgical and chemical castration.
Ceda GP, Denti L, Ceresini G, Cortellini P, Banchini A, Frattini A, Hoffman AR, Valenti G
Horm Metab Res 1990 Mar;22(3):179-82. doi: 10.1055/s-2007-1004878. PMID: 1693131
Serum gonadotropins and alpha-subunit decline in aging normal postmenopausal women.
Kwekkeboom DJ, de Jong FH, van Hemert AM, Vandenbroucke JP, Valkenburg HA, Lamberts SW
J Clin Endocrinol Metab 1990 Apr;70(4):944-50. doi: 10.1210/jcem-70-4-944. PMID: 1690750

Diagnosis

Pituitary surgery for the management of acromegaly.
Laws ER, Vance ML, Thapar K
Horm Res 2000;53 Suppl 3:71-5. doi: 10.1159/000023538. PMID: 10971109
Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients.
Oliveira MC, Pizarro CB, Cassal A, Cremonese R, Vieira JG
Braz J Med Biol Res 1999 Jan;32(1):73-7. doi: 10.1590/s0100-879x1999000100011. PMID: 10347772
Repression of glycoprotein hormone alpha-subunit gene expression and secretion by activin in alpha T3-1 cells.
Attardi B, Klatt B, Little G
Mol Endocrinol 1995 Dec;9(12):1737-49. doi: 10.1210/mend.9.12.8614410. PMID: 8614410
The significance of alpha-subunit as a tumor marker for gonadotropin-producing pituitary adenomas.
Demura R, Jibiki K, Kubo O, Odagiri E, Demura H, Kitamura K, Shizume K
J Clin Endocrinol Metab 1986 Sep;63(3):564-9. doi: 10.1210/jcem-63-3-564. PMID: 2426298
Pure alpha subunit-secreting pituitary tumors.
Klibanski A, Ridgway EC, Zervas NT
J Neurosurg 1983 Oct;59(4):585-9. doi: 10.3171/jns.1983.59.4.0585. PMID: 6886776

Therapy

Pituitary surgery for the management of acromegaly.
Laws ER, Vance ML, Thapar K
Horm Res 2000;53 Suppl 3:71-5. doi: 10.1159/000023538. PMID: 10971109
Regulation of pituitary glycoprotein alpha-subunit secretion after administration of a luteinizing hormone-releasing hormone antagonist in normal men.
Lindner J, Rivier JE, Vale WW, Pavlou SN
J Clin Endocrinol Metab 1990 Apr;70(4):1219-24. doi: 10.1210/jcem-70-4-1219. PMID: 1690747
Dopaminergic regulation of alpha-subunit secretion and messenger ribonucleic acid levels in alpha-secreting pituitary tumors.
Klibanski A, Shupnik MA, Bikkal HA, Black PM, Kliman B, Zervas NT
J Clin Endocrinol Metab 1988 Jan;66(1):96-102. doi: 10.1210/jcem-66-1-96. PMID: 2447115
Luteinizing hormone-secreting pituitary tumor: biosynthetic characterization and clinical studies.
Klibanski A, Deutsch PJ, Jameson JL, Ridgway EC, Crowley WF, Hsu DW, Habener JF, Black PM
J Clin Endocrinol Metab 1987 Mar;64(3):536-42. doi: 10.1210/jcem-64-3-536. PMID: 3102541
Pituitary and peripheral resistance to thyroid hormone.
Tamagna EI, Carlson HE, Hershman JM, Reed AW
Clin Endocrinol (Oxf) 1979 May;10(5):431-41. doi: 10.1111/j.1365-2265.1979.tb02099.x. PMID: 113140

Prognosis

Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas.
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
J Clin Endocrinol Metab 1998 Jan;83(1):248-52. doi: 10.1210/jcem.83.1.4493. PMID: 9435450
Effects of the gonadotropin-releasing-hormone agonist, D-Trp-6-GnRH, on prolactin secretion in healthy young men.
Stoffel-Wagner B, Sommer L, Bidlingmaier F, Klingmüller D
Horm Res 1995;43(6):266-72. doi: 10.1159/000184307. PMID: 7541770
Gonadotropin and alpha-subunit responses to chronic gonadotropin-releasing hormone analog administration in patients with glycoprotein hormone-secreting pituitary tumors.
Klibanski A, Jameson JL, Biller BM, Crowley WF Jr, Zervas NT, Rivier J, Vale WW, Bikkal H
J Clin Endocrinol Metab 1989 Jan;68(1):81-6. doi: 10.1210/jcem-68-1-81. PMID: 2535852
Luteinizing hormone-secreting pituitary tumor: biosynthetic characterization and clinical studies.
Klibanski A, Deutsch PJ, Jameson JL, Ridgway EC, Crowley WF, Hsu DW, Habener JF, Black PM
J Clin Endocrinol Metab 1987 Mar;64(3):536-42. doi: 10.1210/jcem-64-3-536. PMID: 3102541
Carcinoembryonic antigen, alphafetoprotein and alpha and beta subunits of human chorionic gonadotropin in plasma of children with acute leukaemia.
Wysocki M, Domaniewski J, Balcar-Boroń A, Cetnarowski L, Czerwionka-Szaflarska M, Sujkowska R
Acta Paediatr Hung 1987;28(2):119-25. PMID: 2447919

Clinical prediction guides

Selective GPR55 antagonism reduces chemoresistance in cancer cells.
Singh NS, Bernier M, Wainer IW
Pharmacol Res 2016 Sep;111:757-766. Epub 2016 Jul 14 doi: 10.1016/j.phrs.2016.07.013. PMID: 27423937Free PMC Article
Repression of glycoprotein hormone alpha-subunit gene expression and secretion by activin in alpha T3-1 cells.
Attardi B, Klatt B, Little G
Mol Endocrinol 1995 Dec;9(12):1737-49. doi: 10.1210/mend.9.12.8614410. PMID: 8614410
Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro.
Klibanski A, Alexander JM, Bikkal HA, Hsu DW, Swearingen B, Zervas NT
J Clin Endocrinol Metab 1991 Dec;73(6):1248-55. doi: 10.1210/jcem-73-6-1248. PMID: 1720125
Induction by cycloheximide of the glycoprotein hormone alpha-subunit gene in human tumor cell lines and identification of a possible negative regulatory factor.
Cox GS, Cosgrove DE, Sullivan TT, Haas MJ
J Biol Chem 1990 Aug 5;265(22):13190-7. PMID: 1695903
Gonadotropin and alpha-subunit responses to chronic gonadotropin-releasing hormone analog administration in patients with glycoprotein hormone-secreting pituitary tumors.
Klibanski A, Jameson JL, Biller BM, Crowley WF Jr, Zervas NT, Rivier J, Vale WW, Bikkal H
J Clin Endocrinol Metab 1989 Jan;68(1):81-6. doi: 10.1210/jcem-68-1-81. PMID: 2535852

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