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Immune-Mediated Coagulopathy

MedGen UID:
1391199
•Concept ID:
C4321358
•
Disease or Syndrome

Definition

Disorders of coagulation caused by autoantibodies generated against native coagulation factors or therapeutically-administered hemostatic agents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune-Mediated Coagulopathy

Professional guidelines

PubMed

Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade.
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939

Recent clinical studies

Etiology

Direct and indirect effects of Puumala hantavirus on platelet function.
Schrottmaier WC, Schmuckenschlager A, Thunberg T, Wigren-Byström J, Fors-Connolly AM, Assinger A, Ahlm C, Forsell MNE
Thromb Res 2024 Jan;233:41-54. Epub 2023 Nov 20 doi: 10.1016/j.thromres.2023.11.017. PMID: 38006765

Diagnosis

Direct and indirect effects of Puumala hantavirus on platelet function.
Schrottmaier WC, Schmuckenschlager A, Thunberg T, Wigren-Byström J, Fors-Connolly AM, Assinger A, Ahlm C, Forsell MNE
Thromb Res 2024 Jan;233:41-54. Epub 2023 Nov 20 doi: 10.1016/j.thromres.2023.11.017. PMID: 38006765

Therapy

Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade.
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939
Immune-mediated coagulopathy associated with topical bovine thrombin: review of the pediatric literature.
Rodgers GM
J Pediatr Hematol Oncol 2011 Mar;33(2):86-8. doi: 10.1097/MPH.0b013e3181ff0e43. PMID: 21228719
Thrombin products: economic impact of immune-mediated coagulopathies and practical formulary considerations.
Voils SA
Pharmacotherapy 2009 Jul;29(7 Pt 2):18S-22S. doi: 10.1592/phco.29.pt2.18S. PMID: 19558281
Immune-mediated coagulopathy: a case report.
Naoum JJ
Pharmacotherapy 2009 Jul;29(7 Pt 2):13S-7S. doi: 10.1592/phco.29.pt2.13S. PMID: 19558280

Prognosis

Direct and indirect effects of Puumala hantavirus on platelet function.
Schrottmaier WC, Schmuckenschlager A, Thunberg T, Wigren-Byström J, Fors-Connolly AM, Assinger A, Ahlm C, Forsell MNE
Thromb Res 2024 Jan;233:41-54. Epub 2023 Nov 20 doi: 10.1016/j.thromres.2023.11.017. PMID: 38006765
Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?
Castillo-Martínez D, Torres Z, Amezcua-Guerra LM, Pineda C
Clin Rheumatol 2021 Jul;40(7):3015-3019. Epub 2021 Apr 7 doi: 10.1007/s10067-021-05724-5. PMID: 33826045Free PMC Article
Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade.
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939

Clinical prediction guides

Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?
Castillo-Martínez D, Torres Z, Amezcua-Guerra LM, Pineda C
Clin Rheumatol 2021 Jul;40(7):3015-3019. Epub 2021 Apr 7 doi: 10.1007/s10067-021-05724-5. PMID: 33826045Free PMC Article

Supplemental Content

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