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Increased circulating antimullerian hormone concentration

MedGen UID:
1384754
•Concept ID:
C4476971
•
Finding
Synonyms: Increased antimullerian hormone level; Increased plasma AMH
 
HPO: HP:0031102

Definition

An elevation above the normal range of the antimullerian hormone in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating antimullerian hormone concentration

Recent clinical studies

Etiology

Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Ovarian response to follicle-stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls.
Harrison TNH, Chang RJ
Clin Endocrinol (Oxf) 2022 Sep;97(3):310-318. Epub 2022 Mar 14 doi: 10.1111/cen.14708. PMID: 35244287Free PMC Article
Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.
Zhao L, Pang A
Front Endocrinol (Lausanne) 2020;11:428. Epub 2020 Aug 11 doi: 10.3389/fendo.2020.00428. PMID: 32849258Free PMC Article
Anti-Müllerian hormone levels and risk of cancer: A systematic review.
Verdiesen RMG, van Gils CH, van der Schouw YT, Onland-Moret NC
Maturitas 2020 May;135:53-67. Epub 2020 Mar 9 doi: 10.1016/j.maturitas.2020.03.002. PMID: 32252965
Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women.
Anderson C, Mark Park YM, Stanczyk FZ, Sandler DP, Nichols HB
Fertil Steril 2018 Nov;110(6):1145-1153. doi: 10.1016/j.fertnstert.2018.06.037. PMID: 30396559Free PMC Article

Diagnosis

Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Anti-Müllerian hormone levels and risk of cancer: A systematic review.
Verdiesen RMG, van Gils CH, van der Schouw YT, Onland-Moret NC
Maturitas 2020 May;135:53-67. Epub 2020 Mar 9 doi: 10.1016/j.maturitas.2020.03.002. PMID: 32252965
Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.
Hu KL, Zhao H, Min Z, He Y, Li T, Zhen X, Ren Y, Chang HM, Yu Y, Li R
Reprod Sci 2019 Nov;26(11):1429-1438. Epub 2018 Dec 30 doi: 10.1177/1933719118818899. PMID: 30595091
Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts.
Ge W, Clendenen TV, Afanasyeva Y, Koenig KL, Agnoli C, Brinton LA, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Liu M, Zeleniuch-Jacquotte A
Int J Cancer 2018 Jun 1;142(11):2215-2226. Epub 2018 Feb 8 doi: 10.1002/ijc.31249. PMID: 29315564Free PMC Article
Anti-Müllerian hormone: a unique biochemical marker of gonadal development and fertility in humans.
Zec I, Tislaric-Medenjak D, Megla ZB, Kucak I
Biochem Med (Zagreb) 2011;21(3):219-30. doi: 10.11613/bm.2011.031. PMID: 22420235

Therapy

Ovarian response to follicle-stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls.
Harrison TNH, Chang RJ
Clin Endocrinol (Oxf) 2022 Sep;97(3):310-318. Epub 2022 Mar 14 doi: 10.1111/cen.14708. PMID: 35244287Free PMC Article
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.
Zhao L, Pang A
Front Endocrinol (Lausanne) 2020;11:428. Epub 2020 Aug 11 doi: 10.3389/fendo.2020.00428. PMID: 32849258Free PMC Article
The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis.
El Shamy T, Amer SAK, Mohamed AA, James C, Jayaprakasan K
Acta Obstet Gynecol Scand 2020 Jan;99(1):16-23. Epub 2019 Aug 26 doi: 10.1111/aogs.13698. PMID: 31370100
Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women.
Anderson C, Mark Park YM, Stanczyk FZ, Sandler DP, Nichols HB
Fertil Steril 2018 Nov;110(6):1145-1153. doi: 10.1016/j.fertnstert.2018.06.037. PMID: 30396559Free PMC Article

Prognosis

Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.
Hu KL, Zhao H, Min Z, He Y, Li T, Zhen X, Ren Y, Chang HM, Yu Y, Li R
Reprod Sci 2019 Nov;26(11):1429-1438. Epub 2018 Dec 30 doi: 10.1177/1933719118818899. PMID: 30595091
Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
Sahmay S, Atakul N, Oncul M, Tuten A, Aydogan B, Seyisoglu H
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):157-61. Epub 2013 Jun 24 doi: 10.1016/j.ejogrb.2013.05.019. PMID: 23806449
Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels.
Piouka A, Farmakiotis D, Katsikis I, Macut D, Gerou S, Panidis D
Am J Physiol Endocrinol Metab 2009 Feb;296(2):E238-43. Epub 2008 Oct 28 doi: 10.1152/ajpendo.90684.2008. PMID: 18957615

Clinical prediction guides

Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.
Hu KL, Zhao H, Min Z, He Y, Li T, Zhen X, Ren Y, Chang HM, Yu Y, Li R
Reprod Sci 2019 Nov;26(11):1429-1438. Epub 2018 Dec 30 doi: 10.1177/1933719118818899. PMID: 30595091
Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women.
Anderson C, Mark Park YM, Stanczyk FZ, Sandler DP, Nichols HB
Fertil Steril 2018 Nov;110(6):1145-1153. doi: 10.1016/j.fertnstert.2018.06.037. PMID: 30396559Free PMC Article
Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts.
Ge W, Clendenen TV, Afanasyeva Y, Koenig KL, Agnoli C, Brinton LA, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Liu M, Zeleniuch-Jacquotte A
Int J Cancer 2018 Jun 1;142(11):2215-2226. Epub 2018 Feb 8 doi: 10.1002/ijc.31249. PMID: 29315564Free PMC Article
Variation in circulating antimüllerian hormone precursor during the periovulatory and acute postovulatory phases of the human ovarian cycle.
Pankhurst MW, Chong YH
Fertil Steril 2016 Oct;106(5):1238-1243.e2. Epub 2016 Jun 27 doi: 10.1016/j.fertnstert.2016.06.010. PMID: 27362611

Recent systematic reviews

Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.
Zhao L, Pang A
Front Endocrinol (Lausanne) 2020;11:428. Epub 2020 Aug 11 doi: 10.3389/fendo.2020.00428. PMID: 32849258Free PMC Article
Anti-Müllerian hormone levels and risk of cancer: A systematic review.
Verdiesen RMG, van Gils CH, van der Schouw YT, Onland-Moret NC
Maturitas 2020 May;135:53-67. Epub 2020 Mar 9 doi: 10.1016/j.maturitas.2020.03.002. PMID: 32252965
The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis.
El Shamy T, Amer SAK, Mohamed AA, James C, Jayaprakasan K
Acta Obstet Gynecol Scand 2020 Jan;99(1):16-23. Epub 2019 Aug 26 doi: 10.1111/aogs.13698. PMID: 31370100

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