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Hypoploidy

MedGen UID:
137688
•Concept ID:
C0333691
•
Cell or Molecular Dysfunction
Synonyms: Hypodiploid; Hypodiploidy; Hypoploid
SNOMED CT: Hypoploidy (15486006); Hypodiploidy (15486006)

Definition

A chromosomal abnormality in which a somatic cell is missing a single member of one or more pairs of homologous chromosomes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypoploidy

Recent clinical studies

Etiology

Structure and significance of cytogenetic abnormalities in adult patients with Ph-negative acute lymphoblastic leukemia.
Piskunova IS, Obukhova TN, Parovichnikova EN, Kulikov SM, Troitskaya VV, Gavrilina OA, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):30-37. doi: 10.26442/terarkh201890730-37. PMID: 30701920
Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms.
Izumiyama-Shimomura N, Nakamura K, Aida J, Ishikawa N, Kuroiwa M, Hiraishi N, Fujiwara M, Ishikawa Y, Inoshita N, Yonese J, Matsuura M, Poon SS, Arai T, Takubo K
Urol Oncol 2014 Feb;32(2):135-45. Epub 2013 Mar 17 doi: 10.1016/j.urolonc.2012.12.005. PMID: 23510865
Hypoploidy defines patients with poor prognosis in breast cancer.
Chavez-Uribe E, Cameselle-Teijeiro J, Viñuela JE, Castro-Piñeiro C, Gude F, Forteza J, Puente-Domínguez JL
Oncol Rep 2007 May;17(5):1109-14. PMID: 17390052
Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects.
Wojda A, Zietkiewicz E, Witt M
Mutagenesis 2007 May;22(3):195-200. Epub 2007 Feb 6 doi: 10.1093/mutage/gem002. PMID: 17284771
Flow cytometric DNA ploidy defines patients with poor prognosis in node-negative breast cancer.
Balslev I, Christensen IJ, Rasmussen BB, Larsen JK, Lykkesfeldt AE, Thorpe SM, Rose C, Briand P, Mouridsen HT
Int J Cancer 1994 Jan 2;56(1):16-25. doi: 10.1002/ijc.2910560105. PMID: 8262673

Diagnosis

Structure and significance of cytogenetic abnormalities in adult patients with Ph-negative acute lymphoblastic leukemia.
Piskunova IS, Obukhova TN, Parovichnikova EN, Kulikov SM, Troitskaya VV, Gavrilina OA, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):30-37. doi: 10.26442/terarkh201890730-37. PMID: 30701920
Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis.
Lee SY, Park SH, Lee SW, Lee SH, Son MK, Choi YH, Chung WT, Yoo YH
Arch Pharm Res 2014 Oct;37(10):1286-94. Epub 2014 Mar 24 doi: 10.1007/s12272-014-0365-x. PMID: 24988987
Immunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients.
Kim MK, Suh C, Lee DH, Min CK, Kim SJ, Kim K, Moon JH, Yoon SS, Lee GW, Kang HJ, Kim SH, Choi CW, Eom HS, Kwak JY, Kim HJ, Mun YC, Bang SM, Lee K, Shin HJ, Lee JH; Korean Multiple Myeloma Working Party
Ann Oncol 2011 Feb;22(2):411-6. Epub 2010 Aug 2 doi: 10.1093/annonc/mdq393. PMID: 20682550
Interphase fluorescence in situ hybridization in multiple myeloma and monoclonal gammopathy of undetermined significance without and with positive plasma cell identification: analysis of 192 cases from the Region of Southern Denmark.
Christensen JH, Abildgaard N, Plesner T, Nibe A, Nielsen O, Sørensen AG, Kerndrup GB; Leukemia/Lymphoma Study Group, Region of Southern Denmark
Cancer Genet Cytogenet 2007 Apr 15;174(2):89-99. doi: 10.1016/j.cancergencyto.2006.11.015. PMID: 17452249
Sensitization of human ovarian tumor cells by subtoxic CDDP to anti-fas antibody-mediated cytotoxicity and apoptosis.
Uslu R, Jewett A, Bonavida B
Gynecol Oncol 1996 Aug;62(2):282-91. doi: 10.1006/gyno.1996.0228. PMID: 8751562

Therapy

Structure and significance of cytogenetic abnormalities in adult patients with Ph-negative acute lymphoblastic leukemia.
Piskunova IS, Obukhova TN, Parovichnikova EN, Kulikov SM, Troitskaya VV, Gavrilina OA, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):30-37. doi: 10.26442/terarkh201890730-37. PMID: 30701920
Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis.
Lee SY, Park SH, Lee SW, Lee SH, Son MK, Choi YH, Chung WT, Yoo YH
Arch Pharm Res 2014 Oct;37(10):1286-94. Epub 2014 Mar 24 doi: 10.1007/s12272-014-0365-x. PMID: 24988987
Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.
Chiang MF, Yeh ST, Liao HF, Chang NS, Chen YJ
Biomed Pharmacother 2012 Sep;66(6):433-8. Epub 2012 Mar 27 doi: 10.1016/j.biopha.2012.03.003. PMID: 22898080
Sensitization of human ovarian tumor cells by subtoxic CDDP to anti-fas antibody-mediated cytotoxicity and apoptosis.
Uslu R, Jewett A, Bonavida B
Gynecol Oncol 1996 Aug;62(2):282-91. doi: 10.1006/gyno.1996.0228. PMID: 8751562
Genetic effects of marijuana.
Zimmerman S, Zimmerman AM
Int J Addict 1990-1991;25(1A):19-33. doi: 10.3109/10826089009067003. PMID: 2174024

Prognosis

Structure and significance of cytogenetic abnormalities in adult patients with Ph-negative acute lymphoblastic leukemia.
Piskunova IS, Obukhova TN, Parovichnikova EN, Kulikov SM, Troitskaya VV, Gavrilina OA, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):30-37. doi: 10.26442/terarkh201890730-37. PMID: 30701920
Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis.
Lee SY, Park SH, Lee SW, Lee SH, Son MK, Choi YH, Chung WT, Yoo YH
Arch Pharm Res 2014 Oct;37(10):1286-94. Epub 2014 Mar 24 doi: 10.1007/s12272-014-0365-x. PMID: 24988987
Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.
Chiang MF, Yeh ST, Liao HF, Chang NS, Chen YJ
Biomed Pharmacother 2012 Sep;66(6):433-8. Epub 2012 Mar 27 doi: 10.1016/j.biopha.2012.03.003. PMID: 22898080
Hypoploidy defines patients with poor prognosis in breast cancer.
Chavez-Uribe E, Cameselle-Teijeiro J, Viñuela JE, Castro-Piñeiro C, Gude F, Forteza J, Puente-Domínguez JL
Oncol Rep 2007 May;17(5):1109-14. PMID: 17390052
Flow cytometry in primary breast carcinomas: prognostic impact of multiploidy and hypoploidy.
Michels JJ, Duigou F, Marnay J, Denoux Y, Delozier T, Chasle J
Cytometry B Clin Cytom 2003 Sep;55(1):37-45. doi: 10.1002/cyto.b.10040. PMID: 12949958

Clinical prediction guides

Hypoploidy defines patients with poor prognosis in breast cancer.
Chavez-Uribe E, Cameselle-Teijeiro J, Viñuela JE, Castro-Piñeiro C, Gude F, Forteza J, Puente-Domínguez JL
Oncol Rep 2007 May;17(5):1109-14. PMID: 17390052
Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects.
Wojda A, Zietkiewicz E, Witt M
Mutagenesis 2007 May;22(3):195-200. Epub 2007 Feb 6 doi: 10.1093/mutage/gem002. PMID: 17284771
Flow cytometry in primary breast carcinomas: prognostic impact of multiploidy and hypoploidy.
Michels JJ, Duigou F, Marnay J, Denoux Y, Delozier T, Chasle J
Cytometry B Clin Cytom 2003 Sep;55(1):37-45. doi: 10.1002/cyto.b.10040. PMID: 12949958
The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line.
Stillman WS, Varella-Garcia M, Irons RD
Leuk Lymphoma 1999 Oct;35(3-4):269-81. doi: 10.3109/10428199909145730. PMID: 10706450
Flow cytometric DNA ploidy defines patients with poor prognosis in node-negative breast cancer.
Balslev I, Christensen IJ, Rasmussen BB, Larsen JK, Lykkesfeldt AE, Thorpe SM, Rose C, Briand P, Mouridsen HT
Int J Cancer 1994 Jan 2;56(1):16-25. doi: 10.1002/ijc.2910560105. PMID: 8262673

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