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Abnormal response to human chorionic gonadotrophin stimulation test

MedGen UID:
1375972
•Concept ID:
C4476962
•
Finding
Synonym: Abnormal response to hCG stimulation test
 
HPO: HP:0031083

Definition

An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal response to human chorionic gonadotrophin stimulation test

Professional guidelines

PubMed

Estradiol levels in men with congenital hypogonadotropic hypogonadism and the effects of different modalities of hormonal treatment.
Trabado S, Maione L, Salenave S, Baron S, Galland F, Bry-Gauillard H, Guiochon-Mantel A, Chanson P, Pitteloud N, Sinisi AA, Brailly-Tabard S, Young J
Fertil Steril 2011 Jun;95(7):2324-9, 2329.e1-3. Epub 2011 May 4 doi: 10.1016/j.fertnstert.2011.03.091. PMID: 21536274
The hypothalamus-pituitary-gonad axis and testicular function in male patients after treatment for haematological malignancies.
Kauppila M, Viikari J, Irjala K, Koskinen P, Remes K
J Intern Med 1998 Nov;244(5):411-6. doi: 10.1046/j.1365-2796.1998.00390.x. PMID: 9845857
Male pseudohermaphroditism: clinical management, diagnosis and treatment.
Hughes IA, Williams DM, Batch JA, Patterson MN
Horm Res 1992;38 Suppl 2:77-81. doi: 10.1159/000182604. PMID: 1292987

Recent clinical studies

Etiology

Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry.
Roli L, Santi D, Belli S, Tagliavini S, Cavalieri S, De Santis MC, Baraldi E, Fanelli F, Mezzullo M, Granata AR, Pagotto U, Pasquali R, Rochira V, Carani C, Simoni M, Trenti T
J Endocrinol Invest 2017 Aug;40(8):841-850. Epub 2017 Mar 21 doi: 10.1007/s40618-017-0653-7. PMID: 28326509
Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies.
Korevaar TI, Steegers EA, Pop VJ, Broeren MA, Chaker L, de Rijke YB, Jaddoe VW, Medici M, Visser TJ, Tiemeier H, Peeters RP
J Clin Endocrinol Metab 2017 Jan 1;102(1):69-77. doi: 10.1210/jc.2016-2942. PMID: 27754809
Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents.
Ishii T, Matsuo N, Sato S, Ogata T, Tamai S, Anzo M, Kamimaki T, Sasaki G, Inokuchi M, Hori N, Amano N, Narumi S, Shibata H, Hasegawa T
Horm Res Paediatr 2015;84(5):305-10. Epub 2015 Sep 10 doi: 10.1159/000439234. PMID: 26352728
Human chorionic gonadotrophin (HCG) stimulation test and testosterone response in children with micropenis.
Tamunopriye J, Abiola OO
Pediatr Endocrinol Rev 2014 Sep;12(1):42-5. PMID: 25345084

Diagnosis

Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry.
Roli L, Santi D, Belli S, Tagliavini S, Cavalieri S, De Santis MC, Baraldi E, Fanelli F, Mezzullo M, Granata AR, Pagotto U, Pasquali R, Rochira V, Carani C, Simoni M, Trenti T
J Endocrinol Invest 2017 Aug;40(8):841-850. Epub 2017 Mar 21 doi: 10.1007/s40618-017-0653-7. PMID: 28326509
Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents.
Ishii T, Matsuo N, Sato S, Ogata T, Tamai S, Anzo M, Kamimaki T, Sasaki G, Inokuchi M, Hori N, Amano N, Narumi S, Shibata H, Hasegawa T
Horm Res Paediatr 2015;84(5):305-10. Epub 2015 Sep 10 doi: 10.1159/000439234. PMID: 26352728
High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes.
Ma Q, Fan J, Wang J, Yang S, Cong Q, Wang R, Lv Q, Liu R, Ning G
J Mol Endocrinol 2015 Apr;54(2):161-70. Epub 2015 Feb 17 doi: 10.1530/JME-14-0284. PMID: 25691497
Human chorionic gonadotrophin (HCG) stimulation test and testosterone response in children with micropenis.
Tamunopriye J, Abiola OO
Pediatr Endocrinol Rev 2014 Sep;12(1):42-5. PMID: 25345084

Therapy

Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
Oxidative Stress in Response to Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome.
González F, Considine RV, Abdelhadi OA, Acton AJ
J Clin Endocrinol Metab 2019 Nov 1;104(11):5360-5371. doi: 10.1210/jc.2019-00987. PMID: 31298704Free PMC Article
The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry.
Roli L, Santi D, Belli S, Tagliavini S, Cavalieri S, De Santis MC, Baraldi E, Fanelli F, Mezzullo M, Granata AR, Pagotto U, Pasquali R, Rochira V, Carani C, Simoni M, Trenti T
J Endocrinol Invest 2017 Aug;40(8):841-850. Epub 2017 Mar 21 doi: 10.1007/s40618-017-0653-7. PMID: 28326509
Low-dose Human Chorionic Gonadotropin Stimulation Test as a Prognostic Incontinent Indicator in Boys With Bladder Exstrophy-epispadias Complex.
Sabetkish N, Eftekharzadeh S, Elmi A, Talab SS, Kajbafzadeh AM
Urology 2017 Mar;101:133-138. Epub 2016 Dec 27 doi: 10.1016/j.urology.2016.12.034. PMID: 28039050
Gonadal function and response to human chorionic and menopausal gonadotrophin therapy in male patients with idiopathic hypogonadotrophic hypogonadism.
Kirk JM, Savage MO, Grant DB, Bouloux PM, Besser GM
Clin Endocrinol (Oxf) 1994 Jul;41(1):57-63. doi: 10.1111/j.1365-2265.1994.tb03785.x. PMID: 7914153

Prognosis

Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
Diagnostic accuracy of human chorionic gonadotropins (HCG) stimulation test in XY-disorders of sex development (XY-DSD) presented in Armed Forces Institute of Pathology.
Sheikh WH, Asif N, Haroon ZH, Ejaz A, Ain QU, Shehzad N
J Pak Med Assoc 2019 Aug;69(8):1090-1093. PMID: 31431758
Low-dose Human Chorionic Gonadotropin Stimulation Test as a Prognostic Incontinent Indicator in Boys With Bladder Exstrophy-epispadias Complex.
Sabetkish N, Eftekharzadeh S, Elmi A, Talab SS, Kajbafzadeh AM
Urology 2017 Mar;101:133-138. Epub 2016 Dec 27 doi: 10.1016/j.urology.2016.12.034. PMID: 28039050
Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies.
Korevaar TI, Steegers EA, Pop VJ, Broeren MA, Chaker L, de Rijke YB, Jaddoe VW, Medici M, Visser TJ, Tiemeier H, Peeters RP
J Clin Endocrinol Metab 2017 Jan 1;102(1):69-77. doi: 10.1210/jc.2016-2942. PMID: 27754809
Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents.
Ishii T, Matsuo N, Sato S, Ogata T, Tamai S, Anzo M, Kamimaki T, Sasaki G, Inokuchi M, Hori N, Amano N, Narumi S, Shibata H, Hasegawa T
Horm Res Paediatr 2015;84(5):305-10. Epub 2015 Sep 10 doi: 10.1159/000439234. PMID: 26352728

Clinical prediction guides

Predictors of reproductive and non-reproductive outcomes of gonadotropin mediated pubertal induction in male patients with congenital hypogonadotropic hypogonadism (CHH).
Cangiano B, Goggi G, Federici S, Bresesti C, Cotellessa L, Guizzardi F, Vezzoli V, Duminuco P, Persani L, Bonomi M
J Endocrinol Invest 2021 Nov;44(11):2445-2454. Epub 2021 Mar 18 doi: 10.1007/s40618-021-01556-x. PMID: 33738751Free PMC Article
Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
Diagnostic accuracy of human chorionic gonadotropins (HCG) stimulation test in XY-disorders of sex development (XY-DSD) presented in Armed Forces Institute of Pathology.
Sheikh WH, Asif N, Haroon ZH, Ejaz A, Ain QU, Shehzad N
J Pak Med Assoc 2019 Aug;69(8):1090-1093. PMID: 31431758
Low-dose Human Chorionic Gonadotropin Stimulation Test as a Prognostic Incontinent Indicator in Boys With Bladder Exstrophy-epispadias Complex.
Sabetkish N, Eftekharzadeh S, Elmi A, Talab SS, Kajbafzadeh AM
Urology 2017 Mar;101:133-138. Epub 2016 Dec 27 doi: 10.1016/j.urology.2016.12.034. PMID: 28039050
Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents.
Ishii T, Matsuo N, Sato S, Ogata T, Tamai S, Anzo M, Kamimaki T, Sasaki G, Inokuchi M, Hori N, Amano N, Narumi S, Shibata H, Hasegawa T
Horm Res Paediatr 2015;84(5):305-10. Epub 2015 Sep 10 doi: 10.1159/000439234. PMID: 26352728

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