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Subglottis squamous cell carcinoma

MedGen UID:
124720
•Concept ID:
C0280326
•
Neoplastic Process
Synonyms: Epidermoid Carcinoma of Subglottis; epidermoid carcinoma of subglottis; Epidermoid Carcinoma of the Subglottis; epidermoid carcinoma of the subglottis; Squamous Cell Carcinoma of Subglottis; squamous cell carcinoma of subglottis; Squamous Cell Carcinoma of the Subglottis; squamous cell carcinoma of the subglottis; Subglottic Epidermoid Carcinoma; subglottic epidermoid carcinoma; Subglottic Squamous Cell Carcinoma; subglottic squamous cell carcinoma; Subglottis Epidermoid Carcinoma; subglottis epidermoid carcinoma; Subglottis Squamous Cell Carcinoma; subglottis squamous cell carcinoma
 
Monarch Initiative: MONDO:0004291

Definition

A squamous cell carcinoma of the larynx that arises from the subglottic area. Symptoms include dyspnea and stridor. It spreads to the hypopharynx, trachea, and thyroid gland. [from NCI]

Professional guidelines

PubMed

Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/persistent laryngeal cancer.
Farrag TY, Lin FR, Cummings CW, Koch WM, Flint PW, Califano JA, Broussard J, Bajaj G, Tufano RP
Laryngoscope 2006 Oct;116(10):1864-6. doi: 10.1097/01.mlg.0000234917.08822.cd. PMID: 17003711
Surgical treatment of laryngeal carcinoma with subglottis involvement.
Chiesa F, Tradati N, Calabrese L, Zurrida S, DePaoli F, Costa L, Molinari R
Oncol Rep 2001 Jan-Feb;8(1):137-40. PMID: 11115585
The pathology and management of subglottic cancer.
Ferlito A, Rinaldo A
Eur Arch Otorhinolaryngol 2000;257(3):168-73. doi: 10.1007/s004050050217. PMID: 10839493

Recent clinical studies

Etiology

Advances in Organ Preservation for Laryngeal Cancer.
Campbell G, Glazer TA, Kimple RJ, Bruce JY
Curr Treat Options Oncol 2022 Apr;23(4):594-608. Epub 2022 Mar 18 doi: 10.1007/s11864-022-00945-5. PMID: 35303749Free PMC Article
Risk factors and survival outcomes of laryngeal squamous cell carcinoma patients with lung metastasis: A population-based study.
Yang W, Mei X, Zhou Y, Su R, Lei W, Zheng S, Zhu R, Guo L, Tao Y, Su Y, Li J, Ding C, Zou S, Li X, Hu H
Auris Nasus Larynx 2021 Aug;48(4):723-730. Epub 2020 Dec 24 doi: 10.1016/j.anl.2020.11.009. PMID: 33358379
Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx.
Mangussi-Gomes J, Danelon-Leonhardt F, Moussalem GF, Ahumada NG, Oliveira CL, Hojaij FC
Braz J Otorhinolaryngol 2017 May-Jun;83(3):269-275. Epub 2016 May 7 doi: 10.1016/j.bjorl.2016.03.019. PMID: 27209377Free PMC Article
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases.
Marchiano E, Patel DM, Patel TD, Patel AA, Xue YE, Eloy JA, Baredes S, Park RC
Otolaryngol Head Neck Surg 2016 Feb;154(2):315-21. Epub 2015 Nov 25 doi: 10.1177/0194599815618190. PMID: 26607281
Squamous cell carcinoma of the subglottis.
Garas J, McGuirt WF Sr
Am J Otolaryngol 2006 Jan-Feb;27(1):1-4. doi: 10.1016/j.amjoto.2005.05.004. PMID: 16360814

Diagnosis

Non-epithelial tumors of the larynx: case series of 12 years.
Saraydaroglu O, Narter S, Ozsen M, Coskun H
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2843-2847. Epub 2019 Jun 29 doi: 10.1007/s00405-019-05527-0. PMID: 31256243
Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases.
Marchiano E, Patel DM, Patel TD, Patel AA, Xue YE, Eloy JA, Baredes S, Park RC
Otolaryngol Head Neck Surg 2016 Feb;154(2):315-21. Epub 2015 Nov 25 doi: 10.1177/0194599815618190. PMID: 26607281
Squamous cell carcinoma of the subglottis.
Garas J, McGuirt WF Sr
Am J Otolaryngol 2006 Jan-Feb;27(1):1-4. doi: 10.1016/j.amjoto.2005.05.004. PMID: 16360814
The pathology and management of subglottic cancer.
Ferlito A, Rinaldo A
Eur Arch Otorhinolaryngol 2000;257(3):168-73. doi: 10.1007/s004050050217. PMID: 10839493

Therapy

Paratracheal lymph node dissection during total (pharyngo-)laryngectomy: A systematic review and meta-analysis.
Chabrillac E, Jackson R, Mattei P, D'Andréa G, Vergez S, Dupret-Bories A, Edafe O
Oral Oncol 2022 Sep;132:106017. Epub 2022 Jul 10 doi: 10.1016/j.oraloncology.2022.106017. PMID: 35830760
Advances in Organ Preservation for Laryngeal Cancer.
Campbell G, Glazer TA, Kimple RJ, Bruce JY
Curr Treat Options Oncol 2022 Apr;23(4):594-608. Epub 2022 Mar 18 doi: 10.1007/s11864-022-00945-5. PMID: 35303749Free PMC Article
Non-epithelial tumors of the larynx: case series of 12 years.
Saraydaroglu O, Narter S, Ozsen M, Coskun H
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2843-2847. Epub 2019 Jun 29 doi: 10.1007/s00405-019-05527-0. PMID: 31256243
Retrospective analysis: concurrent chemoradiotherapy and adjuvant chemotherapy for T2N0 glottic squamous cell carcinoma.
Nonoshita T, Shioyama Y, Kunitake N, Nakamura K, Nomoto S, Ohga S, Toriya Y, Ono M, Honda H
Fukuoka Igaku Zasshi 2009 Jan;100(1):26-31. PMID: 19378773
Value of computed tomography for evaluating the subglottis in laryngeal and hypopharyngeal squamous cell carcinoma.
de Souza RP, de Barros N, Paes Junior AJ, Tornin Ode S, Rapoport A, Cerri GG
Sao Paulo Med J 2007 Mar 1;125(2):73-6. doi: 10.1590/s1516-31802007000200002. PMID: 17625703Free PMC Article

Prognosis

Risk factors and survival outcomes of laryngeal squamous cell carcinoma patients with lung metastasis: A population-based study.
Yang W, Mei X, Zhou Y, Su R, Lei W, Zheng S, Zhu R, Guo L, Tao Y, Su Y, Li J, Ding C, Zou S, Li X, Hu H
Auris Nasus Larynx 2021 Aug;48(4):723-730. Epub 2020 Dec 24 doi: 10.1016/j.anl.2020.11.009. PMID: 33358379
Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx.
Mangussi-Gomes J, Danelon-Leonhardt F, Moussalem GF, Ahumada NG, Oliveira CL, Hojaij FC
Braz J Otorhinolaryngol 2017 May-Jun;83(3):269-275. Epub 2016 May 7 doi: 10.1016/j.bjorl.2016.03.019. PMID: 27209377Free PMC Article
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases.
Marchiano E, Patel DM, Patel TD, Patel AA, Xue YE, Eloy JA, Baredes S, Park RC
Otolaryngol Head Neck Surg 2016 Feb;154(2):315-21. Epub 2015 Nov 25 doi: 10.1177/0194599815618190. PMID: 26607281
Squamous cell carcinoma of the subglottis.
Garas J, McGuirt WF Sr
Am J Otolaryngol 2006 Jan-Feb;27(1):1-4. doi: 10.1016/j.amjoto.2005.05.004. PMID: 16360814

Clinical prediction guides

Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.
Tang D, Tao L, Zhou L, Zhang M, Wu H, Li X, Chen X, Li C, Xie M, Cheng L
Acta Otolaryngol 2018 Nov;138(11):1043-1050. doi: 10.1080/00016489.2018.1500711. PMID: 30776268
Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx.
Mangussi-Gomes J, Danelon-Leonhardt F, Moussalem GF, Ahumada NG, Oliveira CL, Hojaij FC
Braz J Otorhinolaryngol 2017 May-Jun;83(3):269-275. Epub 2016 May 7 doi: 10.1016/j.bjorl.2016.03.019. PMID: 27209377Free PMC Article
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases.
Marchiano E, Patel DM, Patel TD, Patel AA, Xue YE, Eloy JA, Baredes S, Park RC
Otolaryngol Head Neck Surg 2016 Feb;154(2):315-21. Epub 2015 Nov 25 doi: 10.1177/0194599815618190. PMID: 26607281
Thyroid gland invasion in total laryngectomy and total laryngopharyngectomy: a systematic review and meta-analysis of the English literature.
Kumar R, Drinnan M, Robinson M, Meikle D, Stafford F, Welch A, Zammit-Maempel I, Paleri V
Clin Otolaryngol 2013 Oct;38(5):372-8. doi: 10.1111/coa.12165. PMID: 23998197
Value of computed tomography for evaluating the subglottis in laryngeal and hypopharyngeal squamous cell carcinoma.
de Souza RP, de Barros N, Paes Junior AJ, Tornin Ode S, Rapoport A, Cerri GG
Sao Paulo Med J 2007 Mar 1;125(2):73-6. doi: 10.1590/s1516-31802007000200002. PMID: 17625703Free PMC Article

Recent systematic reviews

Paratracheal lymph node dissection during total (pharyngo-)laryngectomy: A systematic review and meta-analysis.
Chabrillac E, Jackson R, Mattei P, D'Andréa G, Vergez S, Dupret-Bories A, Edafe O
Oral Oncol 2022 Sep;132:106017. Epub 2022 Jul 10 doi: 10.1016/j.oraloncology.2022.106017. PMID: 35830760
Epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer: a systematic review.
Lechien JR, Maniaci A, Hans S, Iannella G, Fakhry N, Mayo-Yáñez M, Ayad T, Mannelli G, Chiesa-Estomba CM
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5741-5753. Epub 2022 Jun 2 doi: 10.1007/s00405-022-07466-9. PMID: 35652941
Thyroid gland invasion in total laryngectomy and total laryngopharyngectomy: a systematic review and meta-analysis of the English literature.
Kumar R, Drinnan M, Robinson M, Meikle D, Stafford F, Welch A, Zammit-Maempel I, Paleri V
Clin Otolaryngol 2013 Oct;38(5):372-8. doi: 10.1111/coa.12165. PMID: 23998197

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