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Teratogenesis

MedGen UID:
115917
•Concept ID:
C0232910
•
Pathologic Function
Synonyms: Teratogenic Effect; Teratogenic effect; Teratogenicity
SNOMED CT: Teratogenesis (58694006); Teratogenic effect (58694006); Teratogenicity (58694006)

Definition

The result of processes that negatively affect a developing fetus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTeratogenesis

Professional guidelines

PubMed

Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy.
Tomson T, Battino D, Bromley R, Kochen S, Meador K, Pennell P, Thomas SV
Epileptic Disord 2019 Dec 1;21(6):497-517. doi: 10.1684/epd.2019.1105. PMID: 31782407
Pharmacogenetics of adverse reactions to antiepileptic drugs.
Fricke-Galindo I, Jung-Cook H, LLerena A, López-López M
Neurologia (Engl Ed) 2018 Apr;33(3):165-176. Epub 2015 May 11 doi: 10.1016/j.nrl.2015.03.005. PMID: 25976948
Management of epilepsy during pregnancy.
Voinescu PE, Pennell PB
Expert Rev Neurother 2015 Oct;15(10):1171-87. Epub 2015 Sep 1 doi: 10.1586/14737175.2015.1083422. PMID: 26416395Free PMC Article

Recent clinical studies

Etiology

A Potential Role for Neuroinflammation in ADHD.
Vázquez-González D, Carreón-Trujillo S, Alvarez-Arellano L, Abarca-Merlin DM, Domínguez-López P, Salazar-García M, Corona JC
Adv Exp Med Biol 2023;1411:327-356. doi: 10.1007/978-981-19-7376-5_15. PMID: 36949317
Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood.
Chung DD, Pinson MR, Bhenderu LS, Lai MS, Patel RA, Miranda RC
Int J Mol Sci 2021 Aug 16;22(16) doi: 10.3390/ijms22168785. PMID: 34445488Free PMC Article
Pregnancy in Kidney Transplant Recipients.
Gonzalez Suarez ML, Parker AS, Cheungpasitporn W
Adv Chronic Kidney Dis 2020 Nov;27(6):486-498. doi: 10.1053/j.ackd.2020.06.004. PMID: 33328065
Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy.
Tomson T, Battino D, Bromley R, Kochen S, Meador K, Pennell P, Thomas SV
Epileptic Disord 2019 Dec 1;21(6):497-517. doi: 10.1684/epd.2019.1105. PMID: 31782407
Issues for Women with Epilepsy.
Vélez-Ruiz NJ, Pennell PB
Neurol Clin 2016 May;34(2):411-25, ix. Epub 2016 Mar 2 doi: 10.1016/j.ncl.2015.11.009. PMID: 27086987Free PMC Article

Diagnosis

Cancer in pregnancy: overview and epidemiology.
Javitt MC
Abdom Radiol (NY) 2023 May;48(5):1559-1563. Epub 2022 Aug 12 doi: 10.1007/s00261-022-03633-y. PMID: 35960309
Managing Epilepsy in Women.
Gerard EE, Meador KJ
Continuum (Minneap Minn) 2016 Feb;22(1 Epilepsy):204-26. doi: 10.1212/CON.0000000000000270. PMID: 26844738Free PMC Article
Gastrointestinal endoscopy in pregnancy.
Savas N
World J Gastroenterol 2014 Nov 7;20(41):15241-52. doi: 10.3748/wjg.v20.i41.15241. PMID: 25386072Free PMC Article
Maternal phenylketonuria.
Paprocka J, Jamroz E, Wiktor M, Marszał E
Wiad Lek 2009;62(1):11-7. PMID: 19817251
Teratogenesis.
Harris JM 3rd, Pashayan HM
Orthop Clin North Am 1976 Apr;7(2):281-9. PMID: 1264426

Therapy

Women's issues.
Keni R, Mostacci B, Kiteva-Trenchevska G, Licchetta L, Ignjatova L, Thomas S, Meador KJ
Epileptic Disord 2020 Aug 1;22(4):355-363. doi: 10.1684/epd.2020.1173. PMID: 32723702Free PMC Article
Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy.
Tomson T, Battino D, Bromley R, Kochen S, Meador K, Pennell P, Thomas SV
Epileptic Disord 2019 Dec 1;21(6):497-517. doi: 10.1684/epd.2019.1105. PMID: 31782407
Carbamazepine adverse drug reactions.
Fricke-Galindo I, LLerena A, Jung-Cook H, López-López M
Expert Rev Clin Pharmacol 2018 Jul;11(7):705-718. Epub 2018 Jun 19 doi: 10.1080/17512433.2018.1486707. PMID: 29898616
Issues for Women with Epilepsy.
Vélez-Ruiz NJ, Pennell PB
Neurol Clin 2016 May;34(2):411-25, ix. Epub 2016 Mar 2 doi: 10.1016/j.ncl.2015.11.009. PMID: 27086987Free PMC Article
Thalidomide-induced teratogenesis: history and mechanisms.
Vargesson N
Birth Defects Res C Embryo Today 2015 Jun;105(2):140-56. Epub 2015 Jun 4 doi: 10.1002/bdrc.21096. PMID: 26043938Free PMC Article

Prognosis

Gene-Environment Interactions: My Unique Journey.
Nebert DW
Annu Rev Pharmacol Toxicol 2024 Jan 23;64:1-26. Epub 2023 Oct 3 doi: 10.1146/annurev-pharmtox-022323-082311. PMID: 37788491
Cancer in pregnancy: overview and epidemiology.
Javitt MC
Abdom Radiol (NY) 2023 May;48(5):1559-1563. Epub 2022 Aug 12 doi: 10.1007/s00261-022-03633-y. PMID: 35960309
Gastrointestinal endoscopy in pregnancy.
Savas N
World J Gastroenterol 2014 Nov 7;20(41):15241-52. doi: 10.3748/wjg.v20.i41.15241. PMID: 25386072Free PMC Article
Pediatric growth and development.
Winbery S, Blaho K
Optom Clin 1996;5(2):35-59. PMID: 8837126
Retinoids as teratogens.
Soprano DR, Soprano KJ
Annu Rev Nutr 1995;15:111-32. doi: 10.1146/annurev.nu.15.070195.000551. PMID: 8527214

Clinical prediction guides

Gene-Environment Interactions: My Unique Journey.
Nebert DW
Annu Rev Pharmacol Toxicol 2024 Jan 23;64:1-26. Epub 2023 Oct 3 doi: 10.1146/annurev-pharmtox-022323-082311. PMID: 37788491
Metformin use in pregnancy: promises and uncertainties.
Lindsay RS, Loeken MR
Diabetologia 2017 Sep;60(9):1612-1619. Epub 2017 Aug 2 doi: 10.1007/s00125-017-4351-y. PMID: 28770325Free PMC Article
Prenatal exposure to environmental factors and congenital limb defects.
Alexander PG, Clark KL, Tuan RS
Birth Defects Res C Embryo Today 2016 Sep;108(3):243-273. Epub 2016 Oct 21 doi: 10.1002/bdrc.21140. PMID: 27768243
Gastrointestinal endoscopy in pregnancy.
Savas N
World J Gastroenterol 2014 Nov 7;20(41):15241-52. doi: 10.3748/wjg.v20.i41.15241. PMID: 25386072Free PMC Article
Nitric oxide and teratogenesis: an update.
Tiboni GM, Ponzano A
Curr Pharm Des 2014;20(34):5443-7. doi: 10.2174/1381612820666140205150437. PMID: 24502594

Recent systematic reviews

Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.
Pack AM, Oskoui M, Williams Roberson S, Donley DK, French J, Gerard EE, Gloss D, Miller WR, Munger Clary HM, Osmundson SS, McFadden B, Parratt K, Pennell PB, Saade G, Smith DB, Sullivan K, Thomas SV, Tomson T, Dolan O'Brien M, Botchway-Doe K, Silsbee HM, Keezer MR
Neurology 2024 Jun;102(11):e209279. Epub 2024 May 15 doi: 10.1212/WNL.0000000000209279. PMID: 38748979
Adverse fetal and neonatal outcomes following in-utero exposure to oxcarbazepine: A systematic review and meta-analysis.
Athar F, Ehsan M, Farooq M, Lo KB, Cheema HA, Ahmad S, Naveed A, Umer M
Br J Clin Pharmacol 2022 Aug;88(8):3600-3609. Epub 2022 May 29 doi: 10.1111/bcp.15413. PMID: 35591806
Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review.
Zakhem GA, Motosko CC, Mu EW, Ho RS
J Am Acad Dermatol 2019 Apr;80(4):957-969. Epub 2018 Oct 2 doi: 10.1016/j.jaad.2018.09.031. PMID: 30287313
Use of colchicine in pregnancy: a systematic review and meta-analysis.
Indraratna PL, Virk S, Gurram D, Day RO
Rheumatology (Oxford) 2018 Feb 1;57(2):382-387. doi: 10.1093/rheumatology/kex353. PMID: 29029311
Adverse drug reactions induced by valproic acid.
Nanau RM, Neuman MG
Clin Biochem 2013 Oct;46(15):1323-38. Epub 2013 Jun 20 doi: 10.1016/j.clinbiochem.2013.06.012. PMID: 23792104

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