von Willebrand disease type 1
- Synonyms
- VON WILLEBRAND DISEASE, TYPE I; VWD, TYPE 1
- Modes of inheritance
- Autosomal dominant inheritance (Orphanet)
Summary
Excerpted from the GeneReview:- Full text of GeneReview (by section):
- Summary
- GeneReview Scope
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Anne Goodeve
- Paula James
- view full author information
Available tests
Check Related conditions for additional relevant tests.
Clinical tests (30 available)
Clinical features
Help- Abnormality of blood and blood-forming tissues
- Epistaxis
Epistaxis
- MedGen UID: 4996
- Concept ID: C0014591
- Finding: Pathologic Function
Abnormality of blood and blood-forming tissues
- Impaired platelet aggregation
Impaired platelet aggregation
- MedGen UID: 383786
- Concept ID: C1855853
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Menorrhagia
Menorrhagia
- MedGen UID: 44358
- Concept ID: C0025323
- Finding: Pathologic Function
Abnormality of blood and blood-forming tissues
- Persistent bleeding after trauma
Persistent bleeding after trauma
- MedGen UID: 375403
- Concept ID: C1844374
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Prolonged bleeding after dental extraction
Prolonged bleeding after dental extraction
- MedGen UID: 369536
- Concept ID: C1969572
- Finding: Pathologic Function
Abnormality of blood and blood-forming tissues
- Prolonged bleeding after surgery
Prolonged bleeding after surgery
- MedGen UID: 867284
- Concept ID: C4021646
- Finding: Pathologic Function
Abnormality of blood and blood-forming tissues
- Prolonged bleeding time
Prolonged bleeding time
- MedGen UID: 56231
- Concept ID: C0151529
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Prolonged whole-blood clotting time
Prolonged whole-blood clotting time
- MedGen UID: 488780
- Concept ID: C0151563
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Reduced factor VIII activity
Reduced factor VIII activity
- MedGen UID: 892907
- Concept ID: C4025649
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Reduced quantity of Von Willebrand factor
Reduced quantity of Von Willebrand factor
- MedGen UID: 893065
- Concept ID: C4023022
- Finding: Finding
Abnormality of blood and blood-forming tissues
- Epistaxis
- Abnormality of the cardiovascular system
- Aortic valve stenosis
Aortic valve stenosis
- MedGen UID: 1621
- Concept ID: C0003507
- Finding: Pathologic Function
Abnormality of the cardiovascular system
- Gastrointestinal angiodysplasia
Gastrointestinal angiodysplasia
- MedGen UID: 163130
- Concept ID: C0854242
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Joint hemorrhage
Joint hemorrhage
- MedGen UID: 5479
- Concept ID: C0018924
- Finding: Pathologic Function
Abnormality of the cardiovascular system
- Mitral valve prolapse
Mitral valve prolapse
- MedGen UID: 7671
- Concept ID: C0026267
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Aortic valve stenosis
- Abnormality of the digestive system
- Gastrointestinal hemorrhage
Gastrointestinal hemorrhage
- MedGen UID: 8971
- Concept ID: C0017181
- Finding: Pathologic Function
Abnormality of the digestive system
- Gastrointestinal hemorrhage
- Abnormality of the integument
- Bruising susceptibility
Bruising susceptibility
- MedGen UID: 140849
- Concept ID: C0423798
- Finding: Finding
Abnormality of the integument
- Bruising susceptibility
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