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| Status |
Public on Jun 23, 2017 |
| Title |
Newborn Sex-specific Transcriptome Signatures and Gestational Exposure to Fine Particles: Findings from the ENVIRONAGE Birth Cohort |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter < 2.5 µm (PM2.5) in order to elucidate potential underlying mechanisms of action. Whole genome gene expression was investigated in cord blood of 142 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. Daily PM2.5 exposure levels were calculated for each mother’s home address using a spatial-temporal interpolation model in combination with a dispersion model to estimate both long- (annual average before delivery) and short- (last month of pregnancy) term exposure. We explored the association between gene expression levels and PM2.5 exposure, and identified modulated pathways by overrepresentation analysis and gene set enrichment analysis.
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| |
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| Overall design |
Epidemiological study
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| |
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| Contributor(s) |
Winckelmans E, Vrijens K, Tsamou M, Janssen BG, Saenen ND, Roels HA, Kleinjans J, Lefebvre W, Vanpoucke C, de Kok TM, Nawrot TS |
| Citation(s) |
28583124 |
| Submission date |
Jun 15, 2016 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Tim S Nawrot |
| E-mail(s) |
tim.nawrot@uhasselt.be
|
| Phone |
32-11-268382
|
| Organization name |
Hasselt University
|
| Department |
Centre for Environmental Sciences
|
| Street address |
Campus Diepenbeek Agoralaan Gebouw D
|
| City |
Diepenbeek |
| ZIP/Postal code |
3590 |
| Country |
Belgium |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (146)
|
|
| Relations |
| BioProject |
PRJNA325784 |
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