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Series GSE73608 Query DataSets for GSE73608
Status Public on Oct 06, 2015
Title Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Interferon (IFN) beta-1a is an approved treatment for relapsing remitting multiple sclerosis (RRMS) and has been examined for use in secondary progressive multiple sclerosis (SPMS). However, no information regarding blood transcriptional changes induced by IFN treatment in SPMS patients is available.
Our aim was to identify a subgroup of SPMS patients presenting a gene expression signature similar to that of RRMS patients who are clinical responders to IFN treatment.
 
Overall design SPMS patients (n=50, 20 IFN treated and 30 untreated) were classified using unsupervised hierarchical clustering according to IFN inducible gene expression profile identified in RRMS clinical responders to treatment. IFN inducible gene expression profile was determined by finding differentially expressed genes (DEGs) between IFN treated (n=10) and untreated (n=25) RRMS patients.
 
Contributor(s) Gurevich M, Miron G, Falb R, Magalashvili D, Dolev M, Stern Y, Achiron A
Citation(s) 26589141
Submission date Sep 30, 2015
Last update date Mar 11, 2019
Contact name Michael Gurevich
E-mail(s) gurevich@sheba.health.gov.il
Organization name Sheba Medical Center
Department Multiple Sclerosis Center
Lab Neurogenomics
Street address Tel-Hashomer
City Ramat-Gan
ZIP/Postal code 52621
Country Israel
 
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (85)
GSM1898858 8677SP164 SPMS
GSM1898859 8488SP162 SPMS
GSM1898860 7937SP141 SPMS
Relations
BioProject PRJNA297802

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE73608_RAW.tar 176.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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