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| Status |
Public on Apr 01, 2014 |
| Title |
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
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| Summary |
In this study we have identified a new morphological pattern in IMPC defined by the presence of numerous bi-nucleated cells, related to abnormal expression of genes involved in regulation of mitosis. We also demonstrated that IMPC presented tight and adherens junctions proteins expression modifications that could participate to their clinical behavior. We showed that IMPC was associated with a specific genomic profile compared to ER+ grade-matched IDC consisting of gains of 17q, high rates of 17q23 and 17q12 ERBB2 amplifications, losses of heterozygosity of 6q. The putative role of the genes located in this 6q LOH should be further investigated in order to determine if they could play a role in the presence of numerous bi-nucleated cells and inverted polarity of IMPC cells. In addition, we identified two genomic IMPC subsets: the first characterized by numerous amplicons with frequently near-tetraploid cells and the second, associated with different complex gains and losses in addition to 8q gains and 16q losses, and predominantly composed of near-diploïd cells. The observation of two genomic subsets within the IMPC entity suggests the existence of two possible oncogenic mechanisms leading to the development of a single disease.
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| Overall design |
Phenotypical analysis was combined with copy number, genotyping (SNP6.0 Affymetrix) and transcriptomic analyses in a series of 39 pure IMPC. The results were compared to those of 27 ER and grade-matched invasive ductal carcinomas (IDC).
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| Contributor(s) |
Gruel N, Benhamo V, Popova T, Cedenot A, Mariani O, Gautier A, Cascone I, Arnould L, Fréneaux P, Bhalshankar J, Assayag F, Pierron G, Reyal F, Alran S, Cottu P, Fourquet A, Sastre-Garau X, Stern M, Camonis J, Delattre O, Vincent-Salomon A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 04, 2012 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Jaydutt D Bhalshankar |
| E-mail(s) |
jaydutt.bhalshankar@curie.fr
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| Phone |
0330156246517
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| Organization name |
Institut CURIE
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| Department |
INSERM UNIT 830
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| Lab |
Genetics and Biology of Cancer
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| Street address |
26 rue d'Ulm
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| City |
Paris |
| ZIP/Postal code |
75248 |
| Country |
France |
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| Platforms (1) |
| GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
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| Samples (66)
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| Relations |
| BioProject |
PRJNA158289 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE37035_RAW.tar |
2.6 Gb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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