|
| Status |
Public on Jul 21, 2005 |
| Title |
Genome-wide SNP Microarray Mapping in Basal Cell Carcinomas Unveils Uniparental Disomy as a Key Somatic Event. |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Affymetrix 10K SNP mapping arrays were used to profile 14 basal cell carcinomas (BCCs) with matched blood DNA samples. Loss of heterozygosity (LOH) and copy number abnormality (CNA) profiles were derived from each tumour-blood pair.
Keywords: Genomic DNA on Affymetrix 10K SNP array
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| Overall design |
14 BCC/Blood pairs were used in this study to obtain genome-wide SNP profiles. By comparing tumour and blood DNA, LOH for each SNP could be obtained. Signal intensity for each SNP were used to deternime CNA.
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| Contributor(s) |
Teh MT, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM, Philpott MP, Young BD, Kelsell DP |
| Citation(s) |
16204023 |
| Submission date |
Jul 18, 2005 |
| Last update date |
Mar 16, 2012 |
| Contact name |
Muy-Teck Teh |
| E-mail(s) |
m.t.teh@qmul.ac.uk
|
| Phone |
+442078827140
|
| Organization name |
Queen Mary University of London
|
| Department |
Centre for Clinical & Diagnostic Oral Sciences
|
| Lab |
Head & Neck Cancer Unit
|
| Street address |
Blizard Building, 4, Newark Street,
|
| City |
London |
| State/province |
England |
| ZIP/Postal code |
E1 2AT |
| Country |
United Kingdom |
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| Platforms (2) |
| GPL1266 |
[Mapping10K_Xba131] Affymetrix Human Mapping 10K SNP Array |
| GPL2641 |
[Mapping10K_Xba142] Affymetrix Human Mapping 10K 2.0 Array |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA92633 |
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