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    Alpk2 alpha-kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498875, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Alpk2provided by RGD
    Official Full Name
    alpha-kinase 2provided by RGD
    Primary source
    RGD:1564431
    See related
    AllianceGenome:RGD:1564431
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564431
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Predicted to act upstream of or within regulation of gene expression. Predicted to colocalize with basolateral plasma membrane. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 366.7), Muscle (RPKM 153.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (61045717..61161703, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (58775603..58906150, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (60960009..61072116, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS10-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene microRNA 3591 Neighboring gene microRNA 122 Neighboring gene uncharacterized LOC120098336 Neighboring gene uncharacterized LOC134483042 Neighboring gene uncharacterized LOC108348801 Neighboring gene uncharacterized LOC120098182 Neighboring gene MALT1 paracaspase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids. Nishi K, et al. Anticancer Res, 2017 Jul. PMID 28668886
    2. ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model. Yoshida Y, et al. Anticancer Res, 2012 Jun. PMID 22641666
    3. ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. Hofsteen P, et al. iScience, 2018 Apr 27. PMID 29888752, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epicardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway involved in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-protein kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      61045717..61161703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097413.2 → XP_038953341.2  alpha-protein kinase 2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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