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    Ephx3 epoxide hydrolase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366836, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ephx3provided by RGD
    Official Full Name
    epoxide hydrolase 3provided by RGD
    Primary source
    RGD:1307206
    See related
    Ensembl:ENSRNOG00000027319 AllianceGenome:RGD:1307206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abhd9
    Summary
    Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 7.8), Heart (RPKM 4.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11857367..11862674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11206812..11212122, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14212470..14217778, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 1089 Neighboring gene notch receptor 3 Neighboring gene bromodomain containing 4 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Decker M, et al. J Lipid Res, 2012 Oct. PMID 22798687, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in epoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epoxide hydrolase 3
    Names
    abhydrolase domain containing 9
    NP_001102458.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108988.1 → NP_001102458.1  epoxide hydrolase 3

      See identical proteins and their annotated locations for NP_001102458.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K941, D4A4W4
      Related
      ENSRNOP00000030761.4, ENSRNOT00000038961.5
      Conserved Domains (2) summary
      COG0596
      Location:133 → 406
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:140 → 413
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      11857367..11862674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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