Nceh1 neutral cholesterol ester hydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nceh1provided by RGD
Official Full Name: neutral cholesterol ester hydrolase 1provided by RGD
Primary source: RGD:1311104
See related: Ensembl:ENSRNOG00000013313 AllianceGenome:RGD:1311104
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aadacl1; RGD1311104
Summary: Predicted to enable phosphate ion binding activity and serine hydrolase activity. Predicted to be involved in ether lipid metabolic process. Predicted to act upstream of or within SMAD protein signal transduction; protein dephosphorylation; and xenobiotic metabolic process. Predicted to be located in membrane. Orthologous to human NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 281.1), Heart (RPKM 254.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (112003677..112064274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (110074985..110135592)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (112868834..112932622)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131776 (e-PCR)
- UniSTS:215059

RH131558 (e-PCR)
- UniSTS:214841

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylalkylglycerol acetylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables serine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ether lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ether lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neutral cholesterol ester hydrolase 1

Names: 2-acetyl MAGE hydrolase; NCEH; acetylalkylglycerol acetylhydrolase; arylacetamide deacetylase-like 1

NP_001120996.1

EC 3.1.1.71

XP_038957906.1

EC 3.1.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127524.2 → NP_001120996.1 neutral cholesterol ester hydrolase 1

See identical proteins and their annotated locations for NP_001120996.1

Status: PROVISIONAL

Source sequence(s)

BC166533

UniProtKB/Swiss-Prot

B2GV54

UniProtKB/TrEMBL

A0A8I6AE54

Related

ENSRNOP00000017805.5, ENSRNOT00000017805.8

Conserved Domains (2) summary

COG0657
Location:70 → 385

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam07859
Location:109 → 382

Abhydrolase_3; alpha/beta hydrolase fold