ZNF154 zinc finger protein 154 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF154provided by HGNC
Official Full Name: zinc finger protein 154provided by HGNC
Primary source: HGNC:HGNC:12939
See related: Ensembl:ENSG00000179909 MIM:604085; AllianceGenome:HGNC:12939
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: pHZ-92
Summary: This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression: Ubiquitous expression in thyroid (RPKM 3.0), spleen (RPKM 2.6) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (57696275..57709204, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (60793207..60806134, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (58207643..58220572, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells.
Title: Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells.
Assessing ZNF154 methylation in patient plasma as a multicancer marker in liquid biopsies from colon, liver, ovarian and pancreatic cancer patients.
Title: Assessing ZNF154 methylation in patient plasma as a multicancer marker in liquid biopsies from colon, liver, ovarian and pancreatic cancer patients.
Data show a significant association between zinc finger protein 154 (ZNF154) promoter hypermethylation and better postoperative survival.
Title: Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer.
Hypermethylation level of ZNF154 lead to gene expression inhibition and function loss, which contribute to the development and poor outcomes in Prostate cancer. In addition, the mean methylation level of ZNF154 can be used as an independent risk factor to predict biochemical recurrence.
Title: ZNF154 is a promising diagnosis biomarker and predicts biochemical recurrence in prostate cancer.
Epigenetic modifications affecting the promoters of ZNF154, CASP8, and VHL are shared across a vast array of tumor types and may therefore be important for understanding the genomic landscape of cancer.
Title: Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines.
Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 in urine specimens are promising diagnostic biomarkers for bladder cancer recurrence surveillance
Title: Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

19556ht2 (e-PCR)
- UniSTS:527901

RH18014 (e-PCR)
- UniSTS:33829

PMC156606P1 (e-PCR)
- UniSTS:271408

L17796 (e-PCR)
- UniSTS:12896

D15S1477 (e-PCR)
- UniSTS:474482

RH93698 (e-PCR)
- UniSTS:91298

SGC35348 (e-PCR)
- UniSTS:16326

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034060.1 RefSeqGene

Range

5008..17937

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001085384.3 → NP_001078853.1 zinc finger protein 154

See identical proteins and their annotated locations for NP_001078853.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AC004017, CN280337, U20648

Consensus CDS

CCDS42639.1

UniProtKB/Swiss-Prot

A7MCY3, Q13106, Q8IVG7, Q8NAR0

Related

ENSP00000507206.1, ENST00000684351.1

Conserved Domains (5) summary

smart00349
Location:14 → 62

KRAB; krueppel associated box

COG5048
Location:139 → 436

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:359 → 379

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:371 → 396

zf-H2C2_2; Zinc-finger double domain

RNA

NR_110974.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB095924, AC004017, CN280337
NR_110975.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC003006, AC004017, AK092261, CN280337

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

57696275..57709204 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439369.1 → XP_047295325.1 zinc finger protein 154 isoform X1

RNA

XR_007066986.1 RNA Sequence
XR_007066984.1 RNA Sequence
XR_007066985.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

60793207..60806134 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322017.1 → XP_054177992.1 zinc finger protein 154 isoform X1

RNA

XR_008485191.1 RNA Sequence
XR_008485192.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_003444.1: Suppressed sequence

Description

NM_003444.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.