DVL1P1 dishevelled segment polarity protein 1 pseudogene 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DVL1P1provided by HGNC
Official Full Name: dishevelled segment polarity protein 1 pseudogene 1provided by HGNC
Primary source: HGNC:HGNC:3085
See related: MIM:601225; AllianceGenome:HGNC:3085
Gene type: pseudo
RefSeq status: INFERRED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DSH; DVL; DVL1; DVL4; DVL-22; DVL1L1
Summary: Predicted to enable frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway and planar cell polarity pathway involved in neural tube closure. Predicted to be active in cytosol. Implicated in DiGeorge syndrome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 22q11.21; 22q11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (19253131..19253469, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (19629840..19630178, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (19240654..19240992, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A SDC4 deletion construct that interacts inefficiently with Dsh is resistant to Wnt5a-induced degradation.
Title: Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.
Studies identify that CVAK104 as a novel binding partner of Dishevelled (Dvl) and that CVAK104 also interacts with Fzd5.
Title: A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).
These data suggest a relationship between the Wnt-beta-catenin pathway and redox signalling through redox-sensitive association of NRX with Dvl.
Title: The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

dishevelled 1-like 1 (homologous to Drosophila dsh)
dishevelled 4, Drosophila dsh homolog
dishevelled, dsh homolog 1 pseudogene 1
dishevelled, dsh homolog 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.