SSTR5 somatostatin receptor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SSTR5provided by HGNC
Official Full Name: somatostatin receptor 5provided by HGNC
Primary source: HGNC:HGNC:11334
See related: Ensembl:ENSG00000162009 MIM:182455; AllianceGenome:HGNC:11334
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SST5; SS-5-R
Summary: Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (1072747..1081454)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (1084408..1093211)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (1122747..1131454)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic and post-transcriptional regulation of somatostatin receptor subtype 5 (SST5 ) in pituitary and pancreatic neuroendocrine tumors.
Title: Epigenetic and post-transcriptional regulation of somatostatin receptor subtype 5 (SST(5) ) in pituitary and pancreatic neuroendocrine tumors.
Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features, and Somatostatin Analogs Resistance.
Title: Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features, and Somatostatin Analogs Resistance.
Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
Title: Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly.
Title: Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly.
Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
Title: Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
Study of transgenic HP5 mice overexpressing human SSTR5 in pituitary corticotrophs shows that SSTR5-induced miR-449c suppresses both CRHR1 expression and function and concludes that corticotroph SSTR5 attenuates hypothalamic-pituitary-adrenal axis responses via CRHR1 downregulation, suggesting a role for SSTR5 in the pathogenesis of secondary adrenal insufficiency.
Title: Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function.
Somatostatin receptor 5 variant (sst5TMD4) was expressed in a subset of breast cancers, where it correlated with angiogenic markers, lymphatic metastasis, and reduced disease-free survival.
Title: The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients.
sst5TMD4 is overexpressed in PCa, especially in those patients with a worse prognosis, and plays an important pathophysiologic role in PCa, which suggesting its potential as a biomarker and/or therapeutic target
Title: The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer.
In cotransfected HEK-293 cells, SSTR5 and CB1R existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 homodimer and dissociation of CB1R homodimer.
Title: Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1.
Combination treatment increased both SSTR2 and SSTR5 mRNA and protein levels in DU-145 cells. The data suggest that this combination therapy may be a good candidate for patients with advanced metastatic Prostate cancer (PCa) do not respond to androgen deprivation.
Title: Octreotide in combination with AT-101 induces cytotoxicity and apoptosis through up-regulation of somatostatin receptors 2 and 5 in DU-145 prostate cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:568875 (e-PCR)
- UniSTS:157761

G67508 (e-PCR)
- UniSTS:186769

G67509 (e-PCR)
- UniSTS:186770

G67510 (e-PCR)
- UniSTS:186771

NoName (e-PCR)
- UniSTS:494790

NoName (e-PCR)
- UniSTS:480985

RH66813 (e-PCR)
- UniSTS:50681

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables somatostatin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: somatostatin receptor type 5

Names: somatostatin receptor subtype 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016744.1 RefSeqGene

Range

4992..13699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001053.4 → NP_001044.1 somatostatin receptor type 5

See identical proteins and their annotated locations for NP_001044.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC009041

Consensus CDS

CCDS10429.1

UniProtKB/Swiss-Prot

P34988, P35346, Q541E0, Q9UJI5

Related

ENSP00000293897.4, ENST00000293897.7

Conserved Domains (2) summary

pfam00001
Location:57 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 319

7tm_4; Olfactory receptor
NM_001172560.3 → NP_001166031.1 somatostatin receptor type 5

See identical proteins and their annotated locations for NP_001166031.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC009041

Consensus CDS

CCDS10429.1

UniProtKB/Swiss-Prot

P34988, P35346, Q541E0, Q9UJI5

Related

ENSP00000508487.1, ENST00000689027.1

Conserved Domains (2) summary

pfam00001
Location:57 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 319

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

1072747..1081454

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

1084408..1093211

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001172572.1: Suppressed sequence

Description

NM_001172572.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and it aligns with non-consensus splice sites.
NM_001172573.1: Suppressed sequence

Description

NM_001172573.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and it aligns with non-consensus splice sites.