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    RPL18 ribosomal protein L18 [ Homo sapiens (human) ]

    Gene ID: 6141, updated on 5-May-2024

    Summary

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    Official Symbol
    RPL18provided by HGNC
    Official Full Name
    ribosomal protein L18provided by HGNC
    Primary source
    HGNC:HGNC:10310
    See related
    Ensembl:ENSG00000063177 MIM:604179; AllianceGenome:HGNC:10310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L18; eL18; DBA18
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 914.0), lymph node (RPKM 396.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL18 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48615331..48619178, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51609800..51613662, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49118588..49122435, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49057162-49058100 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14898 Neighboring gene family with sequence similarity 83 member E Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49117268-49117444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49117749-49118580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49118581-49119412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49119413-49120243 Neighboring gene sperm acrosome associated 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49121076-49121906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10889 Neighboring gene Sharpr-MPRA regulatory region 2382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49130943-49131443 Neighboring gene sphingosine kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14904 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:49147372-49148073 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148074-49148774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148775-49149475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10896 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene secretory blood group 1, pseudogene Neighboring gene carbonic anhydrase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells. Cervantes-Salazar M, et al. Virology, 2015 Oct. PMID 26092250
    2. Nucleotide and deduced amino acid sequence of human ribosomal protein L18. Puder M, et al. Biochim Biophys Acta, 1993 Oct 19. PMID 8218404
    3. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Kumar KU, et al. Mol Cell Biol, 1999 Feb. PMID 9891046, Free PMC Article
    4. Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oh SM, et al. Oncogene, 2010 Feb 18. PMID 19946338, Free PMC Article
    5. Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. Liang Y, et al. PLoS One, 2014. PMID 24941225, Free PMC Article

    See all (211) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
      Title: Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
    2. Silencing of the RPL-18 does not affect cell translation efficiency or viability, but it reduces significantly viral translation, replication and viral yield, suggesting that the RPL-18 is required during the Dengue virus replicative cycle.
      Title: Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Diamond-Blackfan anemia 18
    MedGen: C5193020 OMIM: 618310 GeneReviews: Diamond-Blackfan Anemia
    		Compare labs

    EBI GWAS Catalog

    Description
    Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
    EBI GWAS Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ribosomal protein L18 (RPL18) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L18 (RPL18), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L18 (RPL18), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L18 (RPL18), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L18 (RPL18), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33938

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL18
    Names
    60S ribosomal protein L18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000979.4 → NP_000970.1  large ribosomal subunit protein eL18 isoform 1

      See identical proteins and their annotated locations for NP_000970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK026558, BM764512
      Consensus CDS
      CCDS12726.1
      UniProtKB/Swiss-Prot
      F8VWC5, Q07020, Q8WTZ6
      UniProtKB/TrEMBL
      J3QQ67
      Related
      ENSP00000447001.1, ENST00000549920.6
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 176
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

    2. NM_001270490.2 → NP_001257419.1  large ribosomal subunit protein eL18 isoform 2

      See identical proteins and their annotated locations for NP_001257419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI921565, CD246847
      Consensus CDS
      CCDS58669.1
      UniProtKB/TrEMBL
      Q0QEW2
      Related
      ENSP00000449204.1, ENST00000552588.5
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 146
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

    RNA

    1. NR_073022.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI921565, BM764512, CD389415
      Related
      ENST00000549370.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48615331..48619178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51609800..51613662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07020.2 GenPept UniProtKB/Swiss-Prot:Q07020

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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