SULT1A3 sulfotransferase family 1A member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT1A3provided by HGNC
Official Full Name: sulfotransferase family 1A member 3provided by HGNC
Primary source: HGNC:HGNC:11455
See related: Ensembl:ENSG00000261052 MIM:600641; AllianceGenome:HGNC:11455
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STM; HAST; HAST3; M-PST; ST1A3; ST1A4; ST1A5; TL-PST; ST1A3/ST1A4
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Expression: Broad expression in duodenum (RPKM 134.6), small intestine (RPKM 93.8) and 23 other tissues See more
Orthologs: all
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Genomic context

Location:: 16p11.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (30199255..30204310)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (30483809..30488863)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (30210576..30215631)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
Title: Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
Title: Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
In Alzheimer's disease patients, there was a significantly lower copy number in SULT1A3 genes compared to controls.
Title: Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.
Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
analysis of the catechin-binding site of SULT1A3
Title: Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.
Our results implied that SULT1A3/4 exhibited bidirectional effect on tumor and normal hepatocytes and may thus provide a novel strategy for hepatocellular carcinoma clinical targeting. In addition, SULT1A3/4 re-expression could serve as a biomarker for hepatocellular carcinoma prognosis.
Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
The present study revealed SULT1A3 as the major human SULT enzyme capable of sulfating dextrorphan
Title: Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.
Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
Title: Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103211 (e-PCR)
- UniSTS:97544

GDB:594646 (e-PCR)
- UniSTS:158001

GDB:435498 (e-PCR)
- UniSTS:157234

RH133600 (e-PCR)
- UniSTS:216883

RH92261 (e-PCR)
- UniSTS:90951

GDB:574035 (e-PCR)
- UniSTS:157787

GDB:579633 (e-PCR)
- UniSTS:157822

RH80591 (e-PCR)
- UniSTS:84371

GDB:626005 (e-PCR)
- UniSTS:158379

GDB:626032 (e-PCR)
- UniSTS:158380

D16S3176 (e-PCR)
- UniSTS:149699

RH69023 (e-PCR)
- UniSTS:89560

GDB:453889 (e-PCR)
- UniSTS:157416

Readthrough SLX1A-SULT1A3

Readthrough gene: SLX1A-SULT1A3, Included gene: SLX1A

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amine sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to dopamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in flavonoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfation	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: sulfotransferase 1A3

Names: Sulfotransferase 1A4; aryl sulfotransferase 1A3/1A4; catecholamine-sulfating phenol sulfotransferase; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulfotransferase 1A5; placental estrogen sulfotransferase; sulfokinase; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3; thermolabile (monoamine, M form) phenol sulfotransferase

NP_808220.1

EC 2.8.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177552.4 → NP_808220.1 sulfotransferase 1A3

See identical proteins and their annotated locations for NP_808220.1

Status: REVIEWED

Source sequence(s)

BC078144, BC144355

Consensus CDS

CCDS10674.1

UniProtKB/Swiss-Prot

B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5

UniProtKB/TrEMBL

B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3

Related

ENSP00000343645.6, ENST00000338971.10

Conserved Domains (1) summary

pfam00685
Location:38 → 287

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

30199255..30204310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

30483809..30488863

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017387.1: Suppressed sequence

Description

NM_001017387.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
NM_003166.3: Suppressed sequence

Description

NM_003166.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.