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    Dus3l dihydrouridine synthase 3 like [ Mus musculus (house mouse) ]

    Gene ID: 224907, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dus3lprovided by MGI
    Official Full Name
    dihydrouridine synthase 3 likeprovided by MGI
    Primary source
    MGI:MGI:2147092
    See related
    Ensembl:ENSMUSG00000007603 AllianceGenome:MGI:2147092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 54.5), ovary adult (RPKM 49.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 D; 17 29.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57069224..57077093)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56764751..56770093)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 4, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:56897018-56897127 Neighboring gene neurturin Neighboring gene STARR-positive B cell enhancer ABC_E5624 Neighboring gene proline rich 22 Neighboring gene regulatory factor X, 2 (influences HLA class II expression) Neighboring gene predicted gene, 41604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56820

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA dihydrouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-dihydrouridine47 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA dihydrouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Names
    mRNA-dihydrouridine synthase DUS3L
    putative zinc finger protein MA23
    NP_001347334.1
    NP_659107.2
    XP_036016453.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360405.1 → NP_001347334.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      CT010491
      UniProtKB/Swiss-Prot
      Q3TZQ1, Q7TT12, Q91XI1
      Conserved Domains (1) summary
      cd02801
      Location:293 → 488
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    2. NM_144858.2 → NP_659107.2  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1

      See identical proteins and their annotated locations for NP_659107.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA123957, BI133429, BM224665, BY295359, CK387816, CX201215, DV647483
      Consensus CDS
      CCDS28914.1
      UniProtKB/Swiss-Prot
      Q3TZQ1, Q7TT12, Q91XI1
      UniProtKB/TrEMBL
      A0A0R4IZY9
      Related
      ENSMUSP00000007747.9, ENSMUST00000007747.10
      Conserved Domains (2) summary
      COG0042
      Location:284 → 563
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:293 → 525
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57069224..57077093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160560.1 → XP_036016453.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

      UniProtKB/Swiss-Prot
      Q3TZQ1, Q7TT12, Q91XI1
      Conserved Domains (2) summary
      cd02801
      Location:293 → 584
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam18044
      Location:111 → 135
      zf-CCCH_4; CCCH-type zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XI1.1 GenPept UniProtKB/Swiss-Prot:Q91XI1

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