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    Mroh1 maestro heat-like repeat family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 223658, updated on 9-May-2024

    Summary

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    Official Symbol
    Mroh1provided by MGI
    Official Full Name
    maestro heat-like repeat family member 1provided by MGI
    Primary source
    MGI:MGI:2442558
    See related
    Ensembl:ENSMUSG00000022558 AllianceGenome:MGI:2442558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Heatr7a; D330001F17Rik
    Summary
    Orthologous to human MROH1 (maestro heat like repeat family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.4), kidney adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 35.8 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76264638..76337239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76380438..76453039)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11592 Neighboring gene STARR-positive B cell enhancer ABC_E1912 Neighboring gene HGH1 homolog Neighboring gene testis-specific serine kinase 5 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis scleraxis bHLH transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E5490 Neighboring gene heat shock factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    maestro heat-like repeat-containing protein family member 1
    Names
    HEAT repeat containing 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162489.1 → NP_001155961.1  maestro heat-like repeat-containing protein family member 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' CDS and UTR compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC155074
      Consensus CDS
      CCDS49652.1
      UniProtKB/TrEMBL
      D3Z624, Q80T84
      Related
      ENSMUSP00000090256.5, ENSMUST00000092595.11

    2. NM_175457.4 → NP_780666.3  maestro heat-like repeat-containing protein family member 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC155074, AC157566, AK052153, AK147897
      Consensus CDS
      CCDS49651.1
      UniProtKB/TrEMBL
      E0CZ22
      Related
      ENSMUSP00000094115.5, ENSMUST00000096385.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76264638..76337239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159337.1 → XP_036015230.1  maestro heat-like repeat-containing protein family member 1 isoform X7

    2. XM_036159338.1 → XP_036015231.1  maestro heat-like repeat-containing protein family member 1 isoform X10

    3. XM_036159339.1 → XP_036015232.1  maestro heat-like repeat-containing protein family member 1 isoform X11

    4. XM_030248484.1 → XP_030104344.1  maestro heat-like repeat-containing protein family member 1 isoform X12

    5. XM_036159343.1 → XP_036015236.1  maestro heat-like repeat-containing protein family member 1 isoform X16

      UniProtKB/TrEMBL
      Q80T84

    6. XM_036159332.1 → XP_036015225.1  maestro heat-like repeat-containing protein family member 1 isoform X1

    7. XM_036159334.1 → XP_036015227.1  maestro heat-like repeat-containing protein family member 1 isoform X3

    8. XM_036159333.1 → XP_036015226.1  maestro heat-like repeat-containing protein family member 1 isoform X2

    9. XM_036159336.1 → XP_036015229.1  maestro heat-like repeat-containing protein family member 1 isoform X4

    10. XM_011245569.1 → XP_011243871.1  maestro heat-like repeat-containing protein family member 1 isoform X5

    11. XM_011245571.1 → XP_011243873.1  maestro heat-like repeat-containing protein family member 1 isoform X8

    12. XM_011245570.1 → XP_011243872.1  maestro heat-like repeat-containing protein family member 1 isoform X6

    13. XM_011245572.1 → XP_011243874.1  maestro heat-like repeat-containing protein family member 1 isoform X9

    14. XM_036159340.1 → XP_036015233.1  maestro heat-like repeat-containing protein family member 1 isoform X13

    15. XM_030248486.2 → XP_030104346.1  maestro heat-like repeat-containing protein family member 1 isoform X14

    16. XM_036159342.1 → XP_036015235.1  maestro heat-like repeat-containing protein family member 1 isoform X15

      Conserved Domains (1) summary
      sd00044
      Location:1211 → 1247
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_003951365.1 RNA Sequence

    2. XR_004938821.1 RNA Sequence

    3. XR_004938822.1 RNA Sequence

    4. XR_004938819.1 RNA Sequence

    5. XR_004938816.1 RNA Sequence

    6. XR_004938817.1 RNA Sequence

    7. XR_004938818.1 RNA Sequence

    8. XR_004938820.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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