egg-3 Protein tyrosine phosphatase-like protein egg-3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: egg-3
Gene description: Protein tyrosine phosphatase-like protein egg-3
Primary source: WormBase:WBGene00009701
Locus tag: CELE_F44F4.2
See related: AllianceGenome:WB:WBGene00009701
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See egg-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (10882408..10884441, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition.
Title: EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans.
EGG-3 is an oocyte protein required for the localization of MBK-2 to the cortex.
Title: Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F44F4.3 (e-PCR)
- UniSTS:307648

F44F4.2 (e-PCR)
- UniSTS:321476

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein tyrosine phosphatase-like protein egg-3

NP_001369855.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10882408..10884441 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383944.2 → NP_001369855.1 Protein tyrosine phosphatase-like protein egg-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20402

Conserved Domains (1) summary

smart00194
Location:207 → 513

PTPc; Protein tyrosine phosphatase, catalytic domain