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    YTH1 cleavage polyadenylation factor RNA-binding subunit YTH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856222, updated on 17-May-2024

    Summary

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    Gene symbol
    YTH1
    Gene description
    cleavage polyadenylation factor RNA-binding subunit YTH1
    Primary source
    FungiDB:YPR107C
    Locus tag
    YPR107C
    See related
    SGD:S000006311; AllianceGenome:SGD:S000006311; VEuPathDB:YPR107C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in mRNA polyadenylation and pre-mRNA cleavage required for polyadenylation. Located in cytosol and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF4 (cleavage and polyadenylation specific factor 4) and CPSF4L (cleavage and polyadenylation specific factor 4 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YTH1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (741438..742064, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG4 Neighboring gene putative protein kinase ISR1 Neighboring gene proteasome regulatory particle lid subunit RPN7 Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. What nuclease cleaves pre-mRNA in the process of polyadenylation? Zarudnaya MI, et al. IUBMB Life, 2002 Jul. PMID 12387572
    2. Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs. Barabino SM, et al. EMBO J, 2000 Jul 17. PMID 10899131, Free PMC Article
    3. Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor. Tacahashi Y, et al. Nucleic Acids Res, 2003 Mar 15. PMID 12626716, Free PMC Article
    4. Fip1 regulates the activity of Poly(A) polymerase through multiple interactions. Helmling S, et al. Mol Cell Biol, 2001 Mar. PMID 11238938, Free PMC Article
    5. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Barabino SM, et al. Genes Dev, 1997 Jul 1. PMID 9224719

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage polyadenylation factor RNA-binding subunit YTH1
    NP_015432.1
    • Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      741438..742064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184204.1 → NP_015432.1  TPA: cleavage polyadenylation factor RNA-binding subunit YTH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015432.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A5, Q06102
      UniProtKB/TrEMBL
      A0A6A5Q2R8, C7GXR8, C8ZJC8, G2WPS3, N1NW39
      Conserved Domains (1) summary
      COG5084
      Location:2 → 208
      YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06102.1

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