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    rassf1 Ras association domain family member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 447811, updated on 11-Apr-2024

    Summary

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    Official Symbol
    rassf1provided by ZNC
    Official Full Name
    Ras association domain family member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-14
    See related
    Ensembl:ENSDARG00000004840 AllianceGenome:ZFIN:ZDB-GENE-040912-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92505; wu:fc17f02; zgc:112224
    Summary
    Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within intracellular signal transduction and regulation of microtubule cytoskeleton organization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in several structures, including immature eye; intermediate cell mass of mesoderm; nervous system; pharyngeal arch; and ventral mesoderm. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rassf1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10643751..10658518)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10614064..10628838)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene RAD54 like 2 Neighboring gene cytochrome b561 family, member D2 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator b Neighboring gene hyaluronidase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A cargo model of yolk syncytial nuclear migration during zebrafish epiboly. Fei Z, et al. Development, 2019 Jan 2. PMID 30509968
    2. Global and gene specific DNA methylation changes during zebrafish development. Fang X, et al. Comp Biochem Physiol B Biochem Mol Biol, 2013 Sep. PMID 23876386, Free PMC Article
    3. Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development. Fang X, et al. Environ Toxicol Pharmacol, 2013 Jul. PMID 23542452, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 1
    Names
    Ras association (RalGDS/AF-6) domain family 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004550.1 → NP_001004550.1  ras association domain-containing protein 1

      See identical proteins and their annotated locations for NP_001004550.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081661
      UniProtKB/TrEMBL
      A0A8M6YX93, Q66HV2
      Related
      ENSDARP00000035351.3, ENSDART00000038465.5
      Conserved Domains (3) summary
      smart00109
      Location:66 → 115
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      pfam16517
      Location:317 → 356
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:218 → 311
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10643751..10658518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353113.2 → XP_017208602.1  ras association domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YX93, Q66HV2
      Conserved Domains (3) summary
      smart00109
      Location:66 → 115
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      pfam16517
      Location:317 → 356
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:218 → 311
      UBQ; Ubiquitin-like proteins

    2. XM_005173951.4 → XP_005174008.1  ras association domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005174008.1

      UniProtKB/TrEMBL
      A0A8M6YX93, Q66HV2
      Related
      ENSDARP00000115000.1, ENSDART00000142265.3
      Conserved Domains (3) summary
      smart00109
      Location:66 → 115
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      pfam16517
      Location:317 → 356
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:218 → 311
      UBQ; Ubiquitin-like proteins

    3. XM_005173952.4 → XP_005174009.1  ras association domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BL97
      Related
      ENSDARP00000119596.2, ENSDART00000145459.3
      Conserved Domains (2) summary
      pfam16517
      Location:294 → 333
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:195 → 288
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version

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