Rfc2 replication factor C subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rfc2provided by RGD
Official Full Name: replication factor C subunit 2provided by RGD
Primary source: RGD:621198
See related: Ensembl:ENSRNOG00000001457 AllianceGenome:RGD:621198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-dependent DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 119.1), Spleen (RPKM 91.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27756920..27770049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (22120449..22133576, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (25130375..25143480, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA clamp loader activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA clamp loader activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	ISO Inferred from Sequence Orthology more info
part_of Ctf18 RFC-like complex	ISS Inferred from Sequence or Structural Similarity more info
part_of DNA replication factor C complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA replication factor C complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: replication factor C subunit 2

Names: activator 1 subunit C2; replication factor C (activator 1) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053786.1 → NP_446238.1 replication factor C subunit 2

See identical proteins and their annotated locations for NP_446238.1

Status: PROVISIONAL

Source sequence(s)

BC082110

UniProtKB/Swiss-Prot

Q641W4

UniProtKB/TrEMBL

A0A8L2Q0Z2, A6J0I4

Related

ENSRNOP00000077503.1, ENSRNOT00000094282.1

Conserved Domains (4) summary

cd00009
Location:46 → 180

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

PLN03025
Location:31 → 343

PLN03025; replication factor C subunit; Provisional

pfam08542
Location:269 → 337

Rep_fac_C; Replication factor C C-terminal domain

pfam16193
Location:203 → 231

AAA_assoc_2; AAA C-terminal domain