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    sgk1 serum/glucocorticoid regulated kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 324140, updated on 27-Mar-2024

    Summary

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    Official Symbol
    sgk1provided by ZNC
    Official Full Name
    serum/glucocorticoid regulated kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2860
    See related
    Ensembl:ENSDARG00000025522 AllianceGenome:ZFIN:ZDB-GENE-030131-2860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sgk; cb1083; wu:fc20a09
    Summary
    Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Acts upstream of or within inflammatory response. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blood vasculature; epidermal cell; epiphysis; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See sgk1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (31640239..31693344, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (31713708..31766796, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene TBP-like 1 Neighboring gene solute carrier family 2 member 12 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene HBS1-like translational GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Li Y, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276417, Free PMC Article
    2. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. Burgon J, et al. J Immunol, 2014 Feb 15. PMID 24431232, Free PMC Article
    3. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
    4. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
    5. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Yang L, et al. Toxicol Sci, 2010 Jun. PMID 20181659

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
      Title: ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk1
    NP_954682.1
    XP_005162356.1
    XP_005162357.1
    XP_005162358.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199212.1 → NP_954682.1  serine/threonine-protein kinase Sgk1

      See identical proteins and their annotated locations for NP_954682.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052134
      UniProtKB/Swiss-Prot
      Q7ZTW4
      Related
      ENSDARP00000031762.5, ENSDART00000035031.7
      Conserved Domains (2) summary
      smart00220
      Location:100 → 357
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05602
      Location:92 → 430
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      31640239..31693344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162299.4 → XP_005162356.1  serine/threonine-protein kinase Sgk1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9E4
      Conserved Domains (2) summary
      smart00220
      Location:265 → 522
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05602
      Location:257 → 595
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    2. XM_005162300.4 → XP_005162357.1  serine/threonine-protein kinase Sgk1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B972
      Conserved Domains (2) summary
      smart00220
      Location:82 → 339
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05602
      Location:74 → 412
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_005162301.4 → XP_005162358.1  serine/threonine-protein kinase Sgk1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B9J1
      Conserved Domains (2) summary
      smart00220
      Location:81 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05602
      Location:73 → 411
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395160.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      31775..37610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZTW4.1 GenPept UniProtKB/Swiss-Prot:Q7ZTW4

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