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    casz1 castor zinc finger 1 [ Danio rerio (zebrafish) ]

    Gene ID: 559053, updated on 27-Mar-2024

    Summary

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    Official Symbol
    casz1provided by ZNC
    Official Full Name
    castor zinc finger 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060130-108
    See related
    Ensembl:ENSDARG00000037030 AllianceGenome:ZFIN:ZDB-GENE-060130-108
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu580; wu:fk85f10
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; cardiovascular system; hindbrain neural plate; musculature system; and nervous system. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28956258..29065553, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (29029717..29139003, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene DNA fragmentation factor, alpha polypeptide Neighboring gene si:dkey-246i21.1 Neighboring gene si:ch211-129o18.4 Neighboring gene TAR DNA binding protein a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Clark KJ, et al. Nat Methods, 2011 Jun. PMID 21552255, Free PMC Article
    2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein castor homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28956258..29065553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162285.4 → XP_005162342.1  zinc finger protein castor homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B956
      Conserved Domains (1) summary
      pfam06752
      Location:796 → 897
      E_Pc_C; Enhancer of Polycomb C-terminus

    2. XM_021469993.1 → XP_021325668.1  zinc finger protein castor homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PFJ4
      Conserved Domains (1) summary
      cl26464
      Location:790 → 975
      Atrophin-1; Atrophin-1 family

    3. XM_021469994.1 → XP_021325669.1  zinc finger protein castor homolog 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PL89
      Related
      ENSDARP00000117224.1, ENSDART00000148257.2
      Conserved Domains (1) summary
      cl26464
      Location:812 → 997
      Atrophin-1; Atrophin-1 family

    4. XM_009296966.3 → XP_009295241.1  zinc finger protein castor homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6A1
      Conserved Domains (1) summary
      pfam06752
      Location:813 → 914
      E_Pc_C; Enhancer of Polycomb C-terminus

    5. XM_005162286.4 → XP_005162343.1  zinc finger protein castor homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B961
      Conserved Domains (1) summary
      pfam06752
      Location:792 → 893
      E_Pc_C; Enhancer of Polycomb C-terminus

    6. XM_005162284.4 → XP_005162341.1  zinc finger protein castor homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B9I3
      Conserved Domains (1) summary
      pfam06752
      Location:802 → 903
      E_Pc_C; Enhancer of Polycomb C-terminus

    7. XM_021469995.1 → XP_021325670.1  zinc finger protein castor homolog 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PWX4
      Conserved Domains (1) summary
      pfam06752
      Location:813 → 914
      E_Pc_C; Enhancer of Polycomb C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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