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    nxn.S nucleoredoxin S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444590, updated on 11-Apr-2024

    Summary

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    Official Symbol
    nxn.S
    Official Full Name
    nucleoredoxin S homeolog
    Primary source
    Xenbase:XB-GENE-1001776
    Locus tag
    XELAEV_18015350mg
    See related
    EnsemblRapid:ENSXLAG00005002751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    nxn
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    Genomic context

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    See nxn.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (87844621..87925734)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (79222513..79303598)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene refilin B S homeolog Neighboring gene VPS53 GARP complex subunit S homeolog Neighboring gene uncharacterized LOC108709637 Neighboring gene mitochondrial rRNA methyltransferase 3 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus. Funato Y, et al. Genes Cells, 2008 Sep. PMID 18691226
    2. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. Funato Y, et al. Nat Cell Biol, 2006 May. PMID 16604061
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus.
      Title: Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC84045

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within circulatory system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoredoxin
    NP_001086161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092692.1 → NP_001086161.1  nucleoredoxin

      See identical proteins and their annotated locations for NP_001086161.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074275
      UniProtKB/Swiss-Prot
      Q6GM16
      UniProtKB/TrEMBL
      A0A974DHV1
      Related
      ENSXLAP00005008162.1, ENSXLAT00005008286.1
      Conserved Domains (3) summary
      cd03009
      Location:155 → 286
      TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...
      cd03071
      Location:291 → 406
      PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...
      cl00388
      Location:33 → 144
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      87844621..87925734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GM16.1 GenPept UniProtKB/Swiss-Prot:Q6GM16

    Gene LinkOut

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