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    RBM15 RNA binding motif protein 15 [ Homo sapiens (human) ]

    Gene ID: 64783, updated on 5-May-2024

    Summary

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    Official Symbol
    RBM15provided by HGNC
    Official Full Name
    RNA binding motif protein 15provided by HGNC
    Primary source
    HGNC:HGNC:14959
    See related
    Ensembl:ENSG00000162775 MIM:606077; AllianceGenome:HGNC:14959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OTT; OTT1; SPEN
    Summary
    Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
    Expression
    Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110339377..110346677)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110354432..110361733)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110881999..110889299)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 4 Neighboring gene uncharacterized LOC124900436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1466 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110837163-110837321 Neighboring gene RBM15 antisense RNA 1 Neighboring gene uncharacterized LOC124904276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene solute carrier family 16 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer. Feng J, et al. Environ Toxicol, 2023 Mar. PMID 36715115
    2. The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma. Ma M, et al. Cell Mol Biol (Noisy-le-grand), 2022 May 22. PMID 35809319
    3. RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes. Meng Y, et al. Cell Death Dis, 2021 Jul 23. PMID 34301919, Free PMC Article
    4. Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells. Yang Y, et al. Leuk Lymphoma, 2012 Nov. PMID 22497198
    5. Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene. Torres L, et al. Pediatr Blood Cancer, 2011 May. PMID 21370421

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory mechanism of RNA binding motif protein 15-mediated N[6] methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
      Title: Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
    2. RBM15-mediating MDR1 mRNA m[6]A methylation regulated by the TGF-beta signaling pathway in paclitaxel-resistant ovarian cancer.
      Title: RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
    3. RBM15 m[6] A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
      Title: RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
    4. Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
      Title: Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
    5. RBM15 silencing promotes ferroptosis by regulating the TGF-beta/Smad2 pathway in lung cancer.
      Title: RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.
    6. Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
      Title: Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
    7. The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.
      Title: The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.
    8. Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.
      Title: Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.
    9. RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
      Title: RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
    10. RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes.
      Title: RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1 PubMed
    Rev rev HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12479, FLJ21943, MGC119584

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dosage compensation by inactivation of X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in placenta blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription of Notch receptor target IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thrombopoietin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 15
    Names
    one twenty two protein
    one twenty-two
    one-twenty two protein 1
    putative RNA-binding protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201545.2 → NP_001188474.1  RNA-binding protein 15 isoform 2

      See identical proteins and their annotated locations for NP_001188474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI863760, AL355488, BC006397, BC098140
      Consensus CDS
      CCDS59198.1
      UniProtKB/TrEMBL
      A0A499FJY3
      Related
      ENSP00000473552.3, ENST00000487146.8
      Conserved Domains (5) summary
      TIGR01622
      Location:624 → 736
      SF-CC1; splicing factor, CC1-like family
      pfam07744
      Location:781 → 954
      SPOC; SPOC domain
      cd12553
      Location:169 → 251
      RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12555
      Location:367 → 453
      RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12557
      Location:456 → 528
      RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

    2. NM_022768.5 → NP_073605.4  RNA-binding protein 15 isoform 1

      See identical proteins and their annotated locations for NP_073605.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AL355488, BC042587, BC047479, BC062316
      Consensus CDS
      CCDS822.1
      UniProtKB/Swiss-Prot
      A1A693, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC9, Q96SD0, Q96T37, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0
      UniProtKB/TrEMBL
      A0A087WWP4
      Related
      ENSP00000358799.3, ENST00000369784.9
      Conserved Domains (5) summary
      TIGR01622
      Location:624 → 736
      SF-CC1; splicing factor, CC1-like family
      pfam07744
      Location:781 → 954
      SPOC; SPOC domain
      cd12553
      Location:169 → 251
      RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12555
      Location:367 → 453
      RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12557
      Location:456 → 528
      RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110339377..110346677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110354432..110361733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014092.1: Suppressed sequence

      Description
      NM_014092.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96T37.2 GenPept UniProtKB/Swiss-Prot:Q96T37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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