prkcsh PRKCSH beta subunit of glucosidase II [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkcshprovided by ZNC
Official Full Name: PRKCSH beta subunit of glucosidase IIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-770
See related: Ensembl:ENSDARG00000004470 AllianceGenome:ZFIN:ZDB-GENE-040426-770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55653
Summary: Predicted to enable calcium ion binding activity and kinase activity. Acts upstream of or within liver development and pronephros development. Predicted to be located in endoplasmic reticulum. Predicted to be part of glucosidase II complex. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (46764038..46795289)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (48811704..48842769)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRKCSH functions as a chaperone-like molecule, which prevents endoplasmic reticulum-associated degradation of TRPP2.
Title: PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pronephros development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of glucosidase II complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucosidase 2 subunit beta

Names: protein kinase C substrate 80K-H

NP_957347.1

EC 2.7.11.1

XP_005164280.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201053.1 → NP_957347.1 glucosidase 2 subunit beta precursor

See identical proteins and their annotated locations for NP_957347.1

Status: PROVISIONAL

Source sequence(s)

BC046883

UniProtKB/TrEMBL

Q802Z2

Related

ENSDARP00000025069.8, ENSDART00000023814.10

Conserved Domains (3) summary

pfam12999
Location:7 → 169

PRKCSH-like; Glucosidase II beta subunit-like

cl03075
Location:348 → 400

GrpE; nucleotide exchange factor GrpE

cl06793
Location:381 → 513

PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

46764038..46795289

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164223.4 → XP_005164280.1 glucosidase 2 subunit beta isoform X1

UniProtKB/TrEMBL

A0A8M2BBI5

Conserved Domains (3) summary

pfam12999
Location:50 → 212

PRKCSH-like; Glucosidase II beta subunit-like

cl03075
Location:391 → 443

GrpE; nucleotide exchange factor GrpE

cl06793
Location:424 → 556

PRKCSH; Glucosidase II beta subunit-like protein