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    CYCD2;1 Cyclin D2;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816782, updated on 7-Sep-2023

    Summary

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    Gene symbol
    CYCD2;1
    Gene description
    Cyclin D2;1
    Primary source
    Araport:AT2G22490
    Locus tag
    AT2G22490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCYCD2;1; Cyclin D2;1; F14M13.11; F14M13_11
    Summary
    encodes a D-type cyclin whose transcription level is regulated by sucrose but not phytohormones or nitrate. Protein physically interacts with CDC2A. CycD2 kinase activity is regulated by sequestration of CycD2 protein in a form inaccessible to immunoprecipitation and probably not complexed to CDC2A.
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    Genomic context

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    See CYCD2;1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (9553797..9556167, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene phosphofructokinase 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancement of secondary xylem cell proliferation by Arabidopsis cyclin D overexpression in tobacco plants. Fujii T, et al. Plant Cell Rep, 2012 Sep. PMID 22547095
    2. The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation. Sanz L, et al. Plant Cell, 2011 Feb. PMID 21357490, Free PMC Article
    3. Ectopic expression of Arabidopsis CYCD2 and CYCD3 in tobacco has distinct effects on the structural organization of the shoot apical meristem. Boucheron E, et al. J Exp Bot, 2005 Jan. PMID 15501911
    4. Sugar control of the plant cell cycle: differential regulation of Arabidopsis D-type cyclin gene expression. Riou-Khamlichi C, et al. Mol Cell Biol, 2000 Jul. PMID 10848578, Free PMC Article
    5. The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. Huntley R, et al. Plant Mol Biol, 1998 May. PMID 9620273

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtcycD2;1-overexpressing tobacco had more secondary xylem cells when compared with control plants.
      Title: Enhancement of secondary xylem cell proliferation by Arabidopsis cyclin D overexpression in tobacco plants.
    2. CYCD2;1 and ICK2/KRP2 are genetically interacting components involved in lateral root induction in response to auxin.
      Title: The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation.
    3. Effect of expression in tobacco on plant shoot apical meristem development.
      Title: Ectopic expression of Arabidopsis CYCD2 and CYCD3 in tobacco has distinct effects on the structural organization of the shoot apical meristem.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202647.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin D2;1
    NP_001189576.1
    • Cyclin D2;1 (CYCD2;1); FUNCTIONS IN: protein binding, cyclin-dependent protein kinase regulator activity; INVOLVED IN: G1 phase of mitotic cell cycle, regulation of cell cycle, response to sucrose stimulus; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: CYCLIN D4;1 (TAIR:AT5G65420.1).
    NP_179835.1
    • Cyclin D2;1 (CYCD2;1); FUNCTIONS IN: protein binding, cyclin-dependent protein kinase regulator activity; INVOLVED IN: G1 phase of mitotic cell cycle, regulation of cell cycle, response to sucrose stimulus; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: CYCLIN D4;1 (TAIR:AT5G65420.1); Has 3365 Blast hits to 3363 proteins in 312 species: Archae - 0; Bacteria - 0; Metazoa - 1602; Fungi - 305; Plants - 1074; Viruses - 0; Other Eukaryotes - 384 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9553797..9556167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127815.4 → NP_179835.1  Cyclin D2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179835.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42752, Q0WRQ1, Q1LYY4
      UniProtKB/TrEMBL
      A0A178VTL9, A0A5S9X0F4
      Conserved Domains (2) summary
      cd20543
      Location:96 → 194
      CYCLIN_AtCycD-like_rpt1; first cyclin box found in plant cyclin-delta family
      cd20544
      Location:200 → 286
      CYCLIN_AtCycD-like_rpt2; second cyclin box found in plant cyclin-delta family

    2. NM_001202647.1 → NP_001189576.1  Cyclin D2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X0F4, F4IJJ3
      Conserved Domains (1) summary
      pfam00134
      Location:65 → 196
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42752.3

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