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    LY75-CD302 LY75-CD302 readthrough [ Homo sapiens (human) ]

    Gene ID: 100526664, updated on 8-Mar-2024

    Summary

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    Official Symbol
    LY75-CD302provided by HGNC
    Official Full Name
    LY75-CD302 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:38828
    See related
    Ensembl:ENSG00000248672 AllianceGenome:HGNC:38828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LY75; CD205; Ly-75; CLEC13B; DEC-205; gp200-MR6
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75 (LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding fusion products that share sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in liver (RPKM 22.9), lung (RPKM 17.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See LY75-CD302 in Genome Data Viewer
    Location:
    2q24.2
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159768628..159904756, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160225996..160363008, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160761267, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene RPS3A pseudogene 13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16696 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:160911725-160912406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:160982362-160982960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037195-161037767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037768-161038339 Neighboring gene integrin subunit beta 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. Kato M, et al. J Biol Chem, 2003 Sep 5. PMID 12824192
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Readthrough LY75-CD302

    Included genes: LY75, CD302

    Homology

    General protein information

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    Preferred Names
    LY75-CD302 fusion protein
    Names
    C-type lectin domain family 13 member B
    DEC-205/DCL-1 fusion
    Lymphocyte antigen 75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198759.1 → NP_001185688.1  LY75-CD302 fusion protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as V34-2) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC009961, AC093873, AY184222
      UniProtKB/Swiss-Prot
      O60449
      Related
      ENSP00000423463.1, ENST00000504764.5
      Conserved Domains (5) summary
      smart00059
      Location:162 → 209
      FN2; Fibronectin type 2 domain
      cd00037
      Location:1115 → 1222
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:361 → 486
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:38 → 112
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:40 → 125
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    2. NM_001198760.1 → NP_001185689.1  LY75-CD302 fusion protein isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as V33-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC009961, AC093873, AY314006
      UniProtKB/Swiss-Prot
      O60449
      Related
      ENSP00000421035.1, ENST00000505052.1
      Conserved Domains (5) summary
      smart00059
      Location:162 → 209
      FN2; Fibronectin type 2 domain
      cd00037
      Location:1115 → 1222
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:361 → 486
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:38 → 112
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:40 → 125
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      159768628..159904756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      160225996..160363008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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