Casp8 caspase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp8provided by MGI
Official Full Name: caspase 8provided by MGI
Primary source: MGI:MGI:1261423
See related: Ensembl:ENSMUSG00000026029 AllianceGenome:MGI:1261423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MACH; Mch5; FLICE; CASP-8
Summary: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]
Expression: Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.3; 1 29.19 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58834553..58886663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58795233..58847503)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1.
Title: Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1.
Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice.
Title: Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice.
Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.
Title: Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Title: Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjogren's Disease.
Title: Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation.
Title: Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation.
Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis.
Title: Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis.
Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection.
Title: Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection.
Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Abeta-induced NLRP3 inflammasome activation.
Title: Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aβ-induced NLRP3 inflammasome activation.
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.
Title: Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.

Submit: New GeneRIF Correction See all GeneRIFs (192)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (18) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit414 (e-PCR), detects polymorphism
- UniSTS:128778

Casp8 (e-PCR), detects polymorphism
- UniSTS:498225

AF067834 (e-PCR)
- UniSTS:158798

Casp8 (e-PCR), detects polymorphism
- UniSTS:141238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables death effector domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables death effector domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	TAS Traceable Author Statement more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in pyroptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of thymocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
part_of Noc1p-Noc2p complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-8

Names: Fas-linked ICE-like protease

NP_001073595.1

EC 3.4.22.61

NP_001264855.2

EC 3.4.22.61

NP_001406970.1

EC 3.4.22.61

NP_001406971.1

EC 3.4.22.61

NP_001406972.1

EC 3.4.22.61

NP_001406973.1

EC 3.4.22.61

NP_001406974.1

EC 3.4.22.61

NP_001406975.1

EC 3.4.22.61

NP_001406976.1

EC 3.4.22.61

NP_001406978.1

EC 3.4.22.61

NP_001406979.1

EC 3.4.22.61

NP_033942.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080126.2 → NP_001073595.1 caspase-8 isoform 1

See identical proteins and their annotated locations for NP_001073595.1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

Consensus CDS

CCDS14979.1

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607, Q4FK85

Related

ENSMUSP00000127375.2, ENSMUST00000165549.8

Conserved Domains (3) summary

cd00032
Location:227 → 479

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 179

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001277926.2 → NP_001264855.2 caspase-8 isoform 1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

Consensus CDS

CCDS78590.1

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607

Related

ENSMUSP00000140335.2, ENSMUST00000190213.2
NM_001420041.1 → NP_001406970.1 caspase-8 isoform 1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607

Related

ENSMUSP00000140546.2, ENSMUST00000191201.7
NM_001420042.1 → NP_001406971.1 caspase-8 isoform 1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607
NM_001420043.1 → NP_001406972.1 caspase-8 isoform 1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607
NM_001420044.1 → NP_001406973.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_001420045.1 → NP_001406974.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_001420046.1 → NP_001406975.1 caspase-8 isoform 4

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_001420047.1 → NP_001406976.1 caspase-8 isoform 5

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_001420049.1 → NP_001406978.1 caspase-8 isoform 5

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_001420050.1 → NP_001406979.1 caspase-8 isoform 6

Status: REVIEWED

Source sequence(s)

AC112968, AC120554
NM_009812.3 → NP_033942.1 caspase-8 isoform 1

See identical proteins and their annotated locations for NP_033942.1

Status: REVIEWED

Source sequence(s)

AC112968, AC120554

Consensus CDS

CCDS14979.1

UniProtKB/Swiss-Prot

O35669, O89110

UniProtKB/TrEMBL

Q3U607, Q4FK85

Related

ENSMUSP00000027189.9, ENSMUST00000027189.15

Conserved Domains (3) summary

cd00032
Location:227 → 479

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 179

DD; Death Domain Superfamily of protein-protein interaction domains