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    Npat nuclear protein in the AT region [ Mus musculus (house mouse) ]

    Gene ID: 244879, updated on 14-May-2024

    Summary

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    Official Symbol
    Npatprovided by MGI
    Official Full Name
    nuclear protein in the AT regionprovided by MGI
    Primary source
    MGI:MGI:107605
    See related
    Ensembl:ENSMUSG00000033054 AllianceGenome:MGI:107605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6820401K01
    Summary
    Predicted to enable protein C-terminus binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within in utero embryonic development. Predicted to be located in Cajal body; Gemini of coiled bodies; and cytoplasm. Predicted to be active in nucleus. Is expressed in inner cell mass. Orthologous to human NPAT (nuclear protein, coactivator of histone transcription). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.3), placenta adult (RPKM 4.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npat in Genome Data Viewer
    Location:
    9 A5.3; 9 29.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53448347..53486867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53536889..53575627)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930550C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897 Neighboring gene STARR-seq mESC enhancer starr_24146 Neighboring gene acetyl-Coenzyme A acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1384 Neighboring gene cullin 5 Neighboring gene predicted gene, 22304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development. Cui Z, et al. J Immunol, 2022 Sep 1. PMID 35922064
    2. Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrest. Di Fruscio M, et al. Mol Cell Biol, 1997 Jul. PMID 9199343, Free PMC Article
    3. The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection. Chen C, et al. PLoS One, 2021. PMID 34197485, Free PMC Article
    4. Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition. Xie RL, et al. Gene, 2007 Nov 1. PMID 17826007, Free PMC Article
    5. NPAT expression is regulated by E2F and is essential for cell cycle progression. Gao G, et al. Mol Cell Biol, 2003 Apr. PMID 12665581, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
      Title: NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
    2. Our data indicates that the function of Npat-dependent Sertoli cells is essential at multiple steps in testis development, and this study also identifies Sertoli cells as a major regulator of germ cell development, which are required to maintain a local growth niche to repress premature mitosis and meiosis of gonocytes.
      Title: Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.
    3. Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
      Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
    4. NPAT links E2F to the activation of S-phase-specific histone gene transcription.
      Title: NPAT expression is regulated by E2F and is essential for cell cycle progression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Gemini of coiled bodies ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein NPAT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081152.2 → NP_001074621.1  protein NPAT isoform 1

      See identical proteins and their annotated locations for NP_001074621.1

      Status: VALIDATED

      Source sequence(s)
      AC156640
      Consensus CDS
      CCDS40637.1
      UniProtKB/Swiss-Prot
      Q8BMA5, Q8BWA9, Q8BY06
      Related
      ENSMUSP00000048709.8, ENSMUST00000035850.8
      Conserved Domains (1) summary
      pfam15712
      Location:755 → 1420
      NPAT_C; NPAT C terminus

    2. NM_001409956.1 → NP_001396885.1  protein NPAT isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156640

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      53448347..53486867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242531.3 → XP_011240833.1  protein NPAT isoform X2

      Conserved Domains (1) summary
      pfam15712
      Location:447 → 1113
      NPAT_C; NPAT C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178905.2: Suppressed sequence

      Description
      NM_178905.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMA5.2 GenPept UniProtKB/Swiss-Prot:Q8BMA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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