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    Cdin1 CDAN1 interacting nuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 399568, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cdin1provided by MGI
    Official Full Name
    CDAN1 interacting nuclease 1provided by MGI
    Primary source
    MGI:MGI:3026886
    See related
    Ensembl:ENSMUSG00000040282 AllianceGenome:MGI:3026886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in erythrocyte differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; retina; submandibular gland primordium; and thymus primordium. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type Ib. Orthologous to human CDIN1 (CDAN1 interacting nuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.0), CNS E18 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdin1 in Genome Data Viewer
    Location:
    2 E4; 2 58.18 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (115411388..115609263)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (115580907..115778774)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110099E03 gene Neighboring gene STARR-seq mESC enhancer starr_05416 Neighboring gene predicted gene, 39911 Neighboring gene STARR-seq mESC enhancer starr_05417 Neighboring gene microRNA 1951 Neighboring gene STARR-seq mESC enhancer starr_05421 Neighboring gene STARR-seq mESC enhancer starr_05422 Neighboring gene predicted gene, 52524 Neighboring gene predicted gene, 31590 Neighboring gene Meis homeobox 2 Neighboring gene STARR-seq mESC enhancer starr_05429 Neighboring gene STARR-seq mESC enhancer starr_05430 Neighboring gene RIKEN cDNA G630016G05 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62402

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CDAN1-interacting nuclease 1
    Names
    protein C15orf41 homolog
    uncharacterized protein C15orf41 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145898.2 → NP_001139370.1  CDAN1-interacting nuclease 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037
      Consensus CDS
      CCDS50662.1
      UniProtKB/TrEMBL
      E9PWV4
      Related
      ENSMUSP00000126772.2, ENSMUST00000166472.8
      Conserved Domains (1) summary
      pfam14811
      Location:135 → 271
      TPD; Protein of unknown function TPD sequence-motif

    2. NM_001409759.1 → NP_001396688.1  CDAN1-interacting nuclease 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    3. NM_001409760.1 → NP_001396689.1  CDAN1-interacting nuclease 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    4. NM_001409761.1 → NP_001396690.1  CDAN1-interacting nuclease 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    5. NM_001409762.1 → NP_001396691.1  CDAN1-interacting nuclease 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    6. NM_001409763.1 → NP_001396692.1  CDAN1-interacting nuclease 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    7. NM_001409764.1 → NP_001396693.1  CDAN1-interacting nuclease 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    8. NM_001409765.1 → NP_001396694.1  CDAN1-interacting nuclease 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    9. NM_001409766.1 → NP_001396695.1  CDAN1-interacting nuclease 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037

    10. NM_207264.5 → NP_997147.3  CDAN1-interacting nuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_997147.3

      Status: VALIDATED

      Source sequence(s)
      AL844544, AL844901, AL929037
      Consensus CDS
      CCDS50663.1
      UniProtKB/Swiss-Prot
      Q3U4G0, Q80WT3, Q8C1X6
      Related
      ENSMUSP00000106543.3, ENSMUST00000110918.3
      Conserved Domains (1) summary
      pfam14811
      Location:132 → 269
      TPD; Protein of unknown function TPD sequence-motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      115411388..115609263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162351.1 → XP_036018244.1  CDAN1-interacting nuclease 1 isoform X3

      Conserved Domains (1) summary
      pfam14811
      Location:119 → 235
      TPD; Protein of unknown function TPD sequence-motif

    2. XM_017319079.2 → XP_017174568.1  CDAN1-interacting nuclease 1 isoform X4

      Conserved Domains (1) summary
      pfam14811
      Location:122 → 229
      TPD; Protein of unknown function TPD sequence-motif

    3. XM_036162350.1 → XP_036018243.1  CDAN1-interacting nuclease 1 isoform X1

      Conserved Domains (1) summary
      pfam14811
      Location:132 → 248
      TPD; Protein of unknown function TPD sequence-motif

    4. XM_036162353.1 → XP_036018246.1  CDAN1-interacting nuclease 1 isoform X5

      Conserved Domains (1) summary
      pfam14811
      Location:132 → 248
      TPD; Protein of unknown function TPD sequence-motif

    5. XM_036162354.1 → XP_036018247.1  CDAN1-interacting nuclease 1 isoform X6

      Conserved Domains (1) summary
      pfam14811
      Location:132 → 248
      TPD; Protein of unknown function TPD sequence-motif

    6. XM_036162352.1 → XP_036018245.1  CDAN1-interacting nuclease 1 isoform X3

      Conserved Domains (1) summary
      pfam14811
      Location:119 → 235
      TPD; Protein of unknown function TPD sequence-motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U4G0.2 GenPept UniProtKB/Swiss-Prot:Q3U4G0

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