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    Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like [ Mus musculus (house mouse) ]

    Gene ID: 50926, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hnrnpdlprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein D-likeprovided by MGI
    Primary source
    MGI:MGI:1355299
    See related
    Ensembl:ENSMUSG00000029328 AllianceGenome:MGI:1355299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JKTBP; Hnrpdl; Hnrnpdl1; hnRNP DL; hnRNP-DL; D5Wsu145e; D5Ertd650e
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within mRNA metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 88.2), CNS E14 (RPKM 86.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E4; 5 48.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100181436..100187769, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100033577..100039936, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene predicted gene, 42127 Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene enolase-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene transmembrane protein 150C Neighboring gene predicted gene, 36167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression. Akagi T, et al. Gene, 2000 Mar 21. PMID 10717477
    2. Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. Boopathi E, et al. J Biol Chem, 2004 Aug 20. PMID 15190078
    3. Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. Tsuchiya N, et al. J Biochem, 1998 Mar. PMID 9538234
    4. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element. Reboll MR, et al. RNA, 2007 Aug. PMID 17592041, Free PMC Article
    5. Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. Sheehan CJ, et al. Development, 2020 Jan 13. PMID 31857347, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein D-like
    Names
    JKT41-binding protein
    hnRNP D-like
    hnRPD-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405515.1 → NP_001392444.1  heterogeneous nuclear ribonucleoprotein D-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124480
      UniProtKB/TrEMBL
      D3YTQ3

    2. NM_001405516.1 → NP_001392445.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124480

    3. NM_001405517.1 → NP_001392446.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124480

    4. NM_001405518.1 → NP_001392447.1  heterogeneous nuclear ribonucleoprotein D-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124480
      Related
      ENSMUSP00000118555.2, ENSMUST00000153442.8

    5. NM_001405519.1 → NP_001392448.1  heterogeneous nuclear ribonucleoprotein D-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124480

    6. NM_016690.5 → NP_057899.2  heterogeneous nuclear ribonucleoprotein D-like isoform 1

      See identical proteins and their annotated locations for NP_057899.2

      Status: VALIDATED

      Source sequence(s)
      AC124480
      Consensus CDS
      CCDS19460.2
      UniProtKB/TrEMBL
      D3YTQ3
      Related
      ENSMUSP00000121005.2, ENSMUST00000128187.8
      Conserved Domains (2) summary
      cd12585
      Location:234 → 308
      RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:149 → 224
      RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

    RNA

    1. NR_152866.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480

    2. NR_175955.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480

    3. NR_175956.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100181436..100187769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535076.5 → XP_006535139.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

      See identical proteins and their annotated locations for XP_006535139.1

      Conserved Domains (2) summary
      cd12585
      Location:234 → 308
      RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:149 → 224
      RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z130.1 GenPept UniProtKB/Swiss-Prot:Q9Z130

    Gene LinkOut

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