Pir pirin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pirprovided by RGD
Official Full Name: pirinprovided by RGD
Primary source: RGD:1359212
See related: Ensembl:ENSRNOG00000003674 AllianceGenome:RGD:1359212
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Predicted to be involved in monocyte differentiation. Predicted to act upstream of or within myeloid cell differentiation. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human PIR (pirin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 61.5), Adrenal (RPKM 57.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33740428..33851049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30108536..30219269, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (31852322..31968152, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables quercetin 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables quercetin 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables quercetin 2,3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in monocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pirin

Names: pirin (iron-binding nuclear protein); probable quercetin 2,3-dioxygenase PIR; probable quercetinase

NP_001009474.1

EC 1.13.11.24

XP_038955818.1

EC 1.13.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009474.1 → NP_001009474.1 pirin

See identical proteins and their annotated locations for NP_001009474.1

Status: PROVISIONAL

Source sequence(s)

BC088290

UniProtKB/Swiss-Prot

Q5M827

UniProtKB/TrEMBL

A0A8I5ZXG1

Related

ENSRNOP00000004884.5, ENSRNOT00000004884.6

Conserved Domains (3) summary

COG1741
Location:17 → 275

YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]

pfam02678
Location:21 → 118

Pirin; Pirin

pfam05726
Location:171 → 277

Pirin_C; Pirin C-terminal cupin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

33740428..33851049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099890.2 → XP_038955818.1 pirin isoform X1

UniProtKB/TrEMBL

A0A8I5ZXG1

Conserved Domains (1) summary

COG1741
Location:31 → 272

YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]