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    A2ML1 alpha-2-macroglobulin like 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 486697, updated on 5-Mar-2024

    Summary

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    Official Symbol
    A2ML1provided by VGNC
    Official Full Name
    alpha-2-macroglobulin like 1provided by VGNC
    Primary source
    VGNC:VGNC:37400
    See related
    Ensembl:ENSCAFG00845029001
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human all
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    Genomic context

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    See A2ML1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (37193157..37223156, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (9742223..9772407)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (9250894..9303905)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (37073782..37103765, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (37108930..37138923, complement)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene polyhomeotic homolog 1 Neighboring gene uncharacterized LOC111092831 Neighboring gene uncharacterized LOC119866426 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal modification protein rimK like family member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-2-macroglobulin-like protein 1; LOW QUALITY PROTEIN: alpha-2-macroglobulin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      37193157..37223156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437910.1 → XP_038293838.1  alpha-2-macroglobulin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S725
      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1109
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    2. XM_038437909.1 → XP_038293837.1  alpha-2-macroglobulin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S725
      Related
      ENSCAFP00845040580.1, ENSCAFT00845051722.1
      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1109
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    3. XM_038437911.1 → XP_038293839.1  alpha-2-macroglobulin-like protein 1 isoform X1

      Conserved Domains (5) summary
      cd02897
      Location:650 → 933
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      37073782..37103765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038514319.1 → XP_038370247.1  alpha-2-macroglobulin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1143
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    2. XM_038514318.1 → XP_038370246.1  alpha-2-macroglobulin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1143
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    3. XM_038514320.1 → XP_038370248.1  alpha-2-macroglobulin-like protein 1 isoform X1

      Conserved Domains (5) summary
      cd02897
      Location:650 → 933
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      37108930..37138923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038640365.1 → XP_038496293.1  alpha-2-macroglobulin-like protein 1 isoform X4

      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1143
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    2. XM_038640364.1 → XP_038496292.1  alpha-2-macroglobulin-like protein 1 isoform X4

      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1143
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    3. XM_038640366.1 → XP_038496294.1  alpha-2-macroglobulin-like protein 1 isoform X1

      Conserved Domains (5) summary
      cd02897
      Location:650 → 933
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      9250894..9303905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038577899.1 → XP_038433827.1  LOW QUALITY PROTEIN: alpha-2-macroglobulin-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8P0SIT8

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9742223..9772407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038459500.1 → XP_038315428.1  alpha-2-macroglobulin-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8P0NQ75
      Conserved Domains (6) summary
      cd02897
      Location:650 → 945
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1056 → 1143
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4

    2. XM_038459501.1 → XP_038315429.1  alpha-2-macroglobulin-like protein 1 isoform X1

      Conserved Domains (5) summary
      cd02897
      Location:650 → 933
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:430 → 520
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:482 → 565
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07703
      Location:158 → 304
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:45 → 142
      MG4; Macroglobulin domain MG4
    Nucleotide Protein
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