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    Mapk4 mitogen-activated protein kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 225724, updated on 12-May-2024

    Summary

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    Official Symbol
    Mapk4provided by MGI
    Official Full Name
    mitogen-activated protein kinase 4provided by MGI
    Primary source
    MGI:MGI:2444559
    See related
    Ensembl:ENSMUSG00000024558 AllianceGenome:MGI:2444559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erk3; Prkm4; p63Mapk; A330097D03Rik
    Summary
    Enables protein heterodimerization activity; protein homodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Located in cytoplasm and nucleus. Is expressed in female associated reproductive structure; ureteric tip; and ureteric trunk. Orthologous to human MAPK4 (mitogen-activated protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mapk4 in Genome Data Viewer
    Location:
    18 E2; 18 50.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74061557..74198643, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73928486..74065434, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene maestro Neighboring gene RIKEN cDNA D730045A05 gene Neighboring gene STARR-seq mESC enhancer starr_45000 Neighboring gene STARR-seq mESC enhancer starr_45001 Neighboring gene predicted gene 9925 Neighboring gene STARR-seq mESC enhancer starr_45002 Neighboring gene predicted gene, 32801 Neighboring gene predicted gene, 57658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, et al. Genes Dev, 2020 Apr 1. PMID 32139423, Free PMC Article
    2. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Marquis M, et al. Mol Cell Biol, 2014 Sep 15. PMID 25002529, Free PMC Article
    3. The non-classical MAP kinase ERK3 controls T cell activation. Marquis M, et al. PLoS One, 2014. PMID 24475167, Free PMC Article
    4. ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. Li S, et al. PLoS One, 2010 Sep 29. PMID 20927325, Free PMC Article
    5. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. García JI, et al. Mamm Genome, 1996 Nov. PMID 8875888

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C/EBPalpha/miR-7 Controls CD4(+) T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice.
      Title: C/EBPα/miR-7 Controls CD4(+) T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice.
    2. targeted deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation, promoting lean phenotype and ameliorating diabetes
      Title: The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation.
    3. Results uncover a unique role for ERK3, dependent on its kinase activity, during T cell development and show that this atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes survival during RAG-mediated rearrangements.
      Title: The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.
    4. The atypical MAPK ERK3 is a new and important regulator of T cell receptor-induced T cell activation.
      Title: The non-classical MAP kinase ERK3 controls T cell activation.
    5. Data suggest that ERK3 is crucial for spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.
      Title: ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis.
    6. Data suggest that Erk4 is dispensable for mouse embryonic development and reveals that Erk3 and Erk4 have acquired specialized functions through evolutionary diversification.
      Title: Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.
    7. a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse
      Title: Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.
    8. Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.
      Title: Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 4
    Names
    ERK-4
    Erk3-related
    MAP kinase 4
    MAPK 4
    extracellular signal-regulated kinase 4
    NP_001347865.1
    NP_766220.2
    XP_006525963.1
    XP_006525964.1
    XP_030106306.1
    XP_030106307.1
    XP_030106308.1
    XP_036017016.1
    XP_036017017.1
    XP_036017018.1
    XP_036017019.1
    XP_036017020.1
    XP_036017021.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360936.1 → NP_001347865.1  mitogen-activated protein kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124367
      Conserved Domains (1) summary
      cl21453
      Location:2 → 172
      PKc_like; Protein Kinases, catalytic domain

    2. NM_172632.2 → NP_766220.2  mitogen-activated protein kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_766220.2

      Status: VALIDATED

      Source sequence(s)
      BC058942, BC094564, CB526503
      Consensus CDS
      CCDS37856.1
      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Related
      ENSMUSP00000089462.4, ENSMUST00000091851.10
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      74061557..74198643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525901.5 → XP_006525964.1  mitogen-activated protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_006525964.1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    2. XM_036161128.1 → XP_036017021.1  mitogen-activated protein kinase 4 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 114
      PKc_like; Protein Kinases, catalytic domain

    3. XM_036161125.1 → XP_036017018.1  mitogen-activated protein kinase 4 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 114
      PKc_like; Protein Kinases, catalytic domain

    4. XM_036161123.1 → XP_036017016.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    5. XM_030250447.2 → XP_030106307.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    6. XM_036161124.1 → XP_036017017.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    7. XM_030250448.1 → XP_030106308.1  mitogen-activated protein kinase 4 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 140
      PKc_like; Protein Kinases, catalytic domain

    8. XM_006525900.4 → XP_006525963.1  mitogen-activated protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_006525963.1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    9. XM_036161126.1 → XP_036017019.1  mitogen-activated protein kinase 4 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 114
      PKc_like; Protein Kinases, catalytic domain

    10. XM_030250446.2 → XP_030106306.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5G0
      UniProtKB/TrEMBL
      Q8BV72
      Conserved Domains (1) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    11. XM_036161127.1 → XP_036017020.1  mitogen-activated protein kinase 4 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 114
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5G0.1 GenPept UniProtKB/Swiss-Prot:Q6P5G0

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