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    Inpp5j inositol polyphosphate 5-phosphatase J [ Mus musculus (house mouse) ]

    Gene ID: 170835, updated on 8-May-2024

    Summary

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    Official Symbol
    Inpp5jprovided by MGI
    Official Full Name
    inositol polyphosphate 5-phosphatase Jprovided by MGI
    Primary source
    MGI:MGI:2158663
    See related
    Ensembl:ENSMUSG00000034570 AllianceGenome:MGI:2158663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pipp; Pib5pa
    Summary
    Enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Acts upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in dendritic shaft; growth cone; and plasma membrane. Is expressed in alimentary system; ear; nervous system; respiratory system; and skeleton. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 37.0), frontal lobe adult (RPKM 26.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 2.45 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3444272..3455521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3494272..3505501, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3352424-3352533 Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene selenoprotein M Neighboring gene smoothelin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3435535-3435644 Neighboring gene STARR-positive B cell enhancer mm9_chr11:3439140-3439441 Neighboring gene predicted gene 11946

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes. Yu H, et al. In Vitro Cell Dev Biol Anim, 2021 Mar. PMID 33537929
    2. The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. Ooms LM, et al. Mol Biol Cell, 2006 Feb. PMID 16280363, Free PMC Article
    3. The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Ooms LM, et al. Cancer Cell, 2015 Aug 10. PMID 26267533
    4. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. Gurung R, et al. J Biol Chem, 2003 Mar 28. PMID 12536145
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.
      Title: Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
    Names
    phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A
    phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase
    phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase
    proline-rich inositol polyphosphate 5-phosphatase
    NP_766027.2
    XP_030101477.1
    XP_030101478.1
    XP_030101479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172439.3 → NP_766027.2  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

      See identical proteins and their annotated locations for NP_766027.2

      Status: VALIDATED

      Source sequence(s)
      BC131634, BY235850, BY629401
      Consensus CDS
      CCDS24364.1
      UniProtKB/Swiss-Prot
      P59644, Q3TDM9
      UniProtKB/TrEMBL
      Q3TBW1
      Related
      ENSMUSP00000046625.6, ENSMUST00000044507.12
      Conserved Domains (3) summary
      cd09094
      Location:420 → 727
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
      PHA03247
      Location:50 → 337
      PHA03247; large tegument protein UL36; Provisional
      pfam17751
      Location:738 → 836
      SKICH; SKICH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3444272..3455521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245617.2 → XP_030101477.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

      UniProtKB/Swiss-Prot
      P59644, Q3TDM9
      UniProtKB/TrEMBL
      Q3TBW1
      Conserved Domains (3) summary
      cd09094
      Location:420 → 727
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
      PHA03247
      Location:50 → 337
      PHA03247; large tegument protein UL36; Provisional
      pfam17751
      Location:738 → 836
      SKICH; SKICH domain

    2. XM_030245618.1 → XP_030101478.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

      UniProtKB/Swiss-Prot
      P59644, Q3TDM9
      UniProtKB/TrEMBL
      Q3TBW1
      Conserved Domains (3) summary
      cd09094
      Location:420 → 727
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
      PHA03247
      Location:50 → 337
      PHA03247; large tegument protein UL36; Provisional
      pfam17751
      Location:738 → 836
      SKICH; SKICH domain

    3. XM_030245619.2 → XP_030101479.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2

      UniProtKB/TrEMBL
      A0A075B6D7
      Related
      ENSMUSP00000139302.2, ENSMUST00000154756.2
      Conserved Domains (3) summary
      cd09094
      Location:420 → 727
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
      PHA03247
      Location:50 → 337
      PHA03247; large tegument protein UL36; Provisional
      pfam17751
      Location:738 → 835
      SKICH; SKICH domain

    RNA

    1. XR_003949330.2 RNA Sequence

    2. XR_003949331.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59644.2 GenPept UniProtKB/Swiss-Prot:P59644

    Gene LinkOut

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