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    NFATC3 nuclear factor of activated T cells 3 [ Bos taurus (cattle) ]

    Gene ID: 541127, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NFATC3provided by VGNC
    Official Full Name
    nuclear factor of activated T cells 3provided by VGNC
    Primary source
    VGNC:VGNC:32033
    See related
    BGD:BT22641; Ensembl:ENSBTAG00000004368
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NFATx
    Orthologs
    human mouse all
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    Genomic context

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    See NFATC3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (35517837..35609581)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene DPEP2 neighbor Neighboring gene DEAD-box helicase 28 Neighboring gene dihydrouridine synthase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene small ribosomal subunit protein uS19-like Neighboring gene phospholipase A2 group XV Neighboring gene solute carrier family 7 member 6 Neighboring gene solute carrier family 7 member 6 opposite strand

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. Rinne A, et al. J Mol Cell Cardiol, 2009 Sep. PMID 19540841, Free PMC Article
    2. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRAF3. Song N, et al. Mol Cell Probes, 2017 Oct. PMID 28627449
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA
      Title: MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRAF3.
    2. regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
      Title: Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor of activated T-cells, cytoplasmic 3
    Names
    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192831.1 → NP_001179760.1  nuclear factor of activated T-cells, cytoplasmic 3

      See identical proteins and their annotated locations for NP_001179760.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000018
      UniProtKB/TrEMBL
      F1MSU2
      Related
      ENSBTAP00000005727.5, ENSBTAT00000005727.7
      Conserved Domains (2) summary
      cd07881
      Location:421 → 594
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:599 → 699
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35517837..35609581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005218707.5 → XP_005218764.1  nuclear factor of activated T-cells, cytoplasmic 3 isoform X2

      See identical proteins and their annotated locations for XP_005218764.1

      UniProtKB/TrEMBL
      A0A3Q1LRX2
      Related
      ENSBTAP00000063040.1, ENSBTAT00000074076.2
      Conserved Domains (2) summary
      cd07881
      Location:421 → 594
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:599 → 699
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

    2. XM_010814549.4 → XP_010812851.2  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1

      Conserved Domains (2) summary
      cd07881
      Location:421 → 594
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:599 → 699
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    Nucleotide Protein Strain
    Heading Accession and Version

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